Search review questions

Changes in intensity of pain (VAS 0 to 10) tested through air blast stimuli · Patients aged above 12 years with self-reported tooth hypersensitivity confirmed on clinical evaluation · Long term (more than 2 months)

Amount of crowding (lower incisor crowding) at 2 years · Children or adolescents (aged 16 years old or under) receiving orthodontic treatment to prevent or correct crowded teeth · 2 years

Dental erosion · Five-year-old preschool children in Sharjah · Overall

MIH prevalence · School-aged children in the United Arab Emirates (Dubai) · Dubai, UAE; governmental/public schools

Average fluorescence loss (dF%) · Adults undergoing orthodontic treatment · 3 months, Adults

All-cause mortality (ACM) · Adults (any age) with a known number of remaining teeth, followed prospectively in cohort studies · Community-based and clinical cohorts worldwide (all continents); events ascertained from medical records, death certificates/registers, or self-report, Adjusted for age/sex

Dental caries prevalence · General Pakistani population (all ages and both sexes; predominantly children and adolescents) · Pakistan (school-, community-, and hospital/clinic-based cross-sectional surveys), Dentition: mixed

All-cause mortality (ACM) · Adults (any age) with a known number of remaining teeth, followed prospectively in cohort studies · Community-based and clinical cohorts worldwide (all continents); events ascertained from medical records, death certificates/registers, or self-report, Multivariable-adjusted

Molar-incisor hypomineralization prevalence · School children aged 8-12 years in Dubai public schools · Overall

Diagnostic accuracy for proximal caries detection (caries detection level) · Extracted permanent posterior teeth with proximal surfaces (in vitro) · In vitro (laboratory; extracted teeth); permanent posterior teeth, proximal surfaces, Caries detection level

Mean dmft · Preschool children in Abu Dhabi nurseries · Emirati children

Endothelial function (flow-mediated dilation) · Adults (any age/sex) with chronic periodontitis (>=5 teeth remaining; PPD >4 mm), with or without hypertension · Long term, People diagnosed with periodontitis

Failure of therapy · Children and/or adults with permanent or primary teeth, vital (sensitive) pulps, and cavitated or dentine carious… · 6-60 months, Deep lesions, permanent dentition

All-cause mortality (ACM) · Adults (any age) with a known number of remaining teeth, followed prospectively in cohort studies · Community-based and clinical cohorts worldwide (all continents); events ascertained from medical records, death certificates/registers, or self-report

Overall survival, induction platinum + 5-fluorouracil prior to surgery vs surgery alone · People receiving curative-intent treatment for oral cavity and oropharyngeal (squamous cell) cancer

Root resorption of adjacent permanent teeth caused by the PDC · Young people aged 9 to 14 years diagnosed with one or both palatally displaced permanent maxillary canines (PDC) · 12 months

Sensitivity for detection of enamel caries · Asymptomatic children or adults presenting for clinical examination (in vivo studies), or extracted teeth of children… · Up to 3 months between index test and reference standard (in vivo studies), Occlusal surface

Diagnostic accuracy for proximal caries detection (caries detection level) · Extracted permanent posterior teeth with proximal surfaces (in vitro) · In vitro (laboratory; extracted teeth); permanent posterior teeth, proximal surfaces, Caries detection level

Diagnostic accuracy for occlusal caries detection at the dentin caries detection level (D0-2 versus D3-4) · Human permanent posterior teeth (premolars and molars) in patients, occlusal (pit-and-fissure) surfaces · in vivo

Failure of therapy · Children and/or adults with permanent or primary teeth, vital (sensitive) pulps, and cavitated or dentine carious… · 24-36 months, Deep lesions, primary dentition

Crossbite correction · Children and adults with a posterior crossbite, without a Class III skeletal relationship, cleft lip or palate (or… · Children (7 to 11 years)

Sensitivity for detection of enamel/early caries · Children or adults presenting asymptomatically or suspected of having enamel caries (clinical/in vivo studies);… · Up to 3 months between index test and reference standard (in vivo; in vitro no limit if stored appropriately)

Canine expansion (inter-canine distance) · Children and adults with a posterior crossbite, without a Class III skeletal relationship, cleft lip or palate (or… · Children (7 to 11 years)

Specificity for detection and diagnosis of early (enamel) caries · Asymptomatic children, adolescents, or adults presenting for clinical examination (in vivo studies), or extracted… · Up to 3 months between index test and reference standard (in vivo studies), Sensitivity analysis: low risk of bias for index test

Optical/esthetic improvement (visual-tactile assessment) · Patients with post-orthodontic white spot lesions (WSL) · 4 weeks to 6 months, Visual analog scale (Senestraro et al. 2013)

Water samples with fluoride concentration below the acceptable range · Region: South Brazil

Canine expansion · Children and adults with a posterior crossbite, without a Class III skeletal relationship, cleft lip or palate (or…

Changes in intensity of pain (VAS 0 to 10) tested through air blast stimuli · Patients aged above 12 years with self-reported tooth hypersensitivity confirmed on clinical evaluation · Short term (0 to 24 hours)

Overall survival, chemotherapy regimen A vs regimen B · People receiving curative-intent treatment for oral cavity and oropharyngeal (squamous cell) cancer

Outcome NR · Children/adolescents/adults or extracted teeth; target condition = non-cavitated enamel caries on SMOOTH tooth surfaces. · Up to 3 months between index test and reference standard (in vivo studies)

Effect of severity of PDC displacement towards the midline on the proportion of successful eruptions · Young people aged 9 to 14 years diagnosed with one or both palatally displaced permanent maxillary canines (PDC) · 12 months, By baseline sector (severity of displacement)

Failure of therapy · Children and/or adults with permanent or primary teeth, vital (sensitive) pulps, and cavitated or dentine carious… · 30-60 months, Cavitated (not deep) lesions, primary dentition

Mean DMFT (decayed, missing, filled permanent teeth) · Individuals with permanent dentition in East Africa · Community- and school-based populations, East Africa, Tanzania

Probing depth (PD) · Adults (general and hospital populations assessed in case-control studies) · Hospital/clinic-based case-control studies from Asia, America and Europe, Asia (Elimelech 2015, Leung 2011, Mayer 2013)

Amount of crowding (change in mandibular crowding) at 10 to 30 weeks · Children or adolescents (aged 16 years old or under) receiving orthodontic treatment to prevent or correct crowded teeth · 10 to 30 weeks

Sensitivity for detection and diagnosis of early (enamel) caries · Asymptomatic children, adolescents, or adults presenting for clinical examination (in vivo studies), or extracted… · Up to 3 months between index test and reference standard (in vivo studies), Reference standard: excavation (non-CBCT)

Adverse events · Patients aged above 12 years with self-reported tooth hypersensitivity confirmed on clinical evaluation · Air blast stimuli studies (SoF 1)

Changes in vertical height of alveolar ridge (mm) · Adults aged 18 years or older, in good general health (including well-controlled systemic disease), requiring… · 6 months

Adverse events (participants with adverse events or withdrawals due to adverse events) · Adults (any age/sex) with chronic periodontitis (>=5 teeth remaining; PPD >4 mm), with or without hypertension

Specificity · Children, adolescents, or adults presenting asymptomatically or suspected of early enamel caries (in vivo), or… · Up to 3 months between index test and reference standard (in vivo studies), Permanent dentition

Full-mouth plaque score (FMPS) · Adolescents/teenagers undergoing orthodontic treatment · 12 months, Adolescents

Mean dmft · Preschoolers (AlKhayat, Dubai)

Dental caries prevalence · Kenya

Restoration failure rate · People with permanent or adult posterior teeth requiring restoration (parallel-group trials involved children aged 6… · Follow-up >= 3 years, Parallel-group and split-mouth trials combined

Change in systolic blood pressure (SBP, mmHg) · Adults (any age/sex) with chronic periodontitis (>=5 teeth remaining; PPD >4 mm), with or without hypertension · Long term (follow-up 12 months), People diagnosed with periodontitis

Dental caries susceptibility (risk of dental caries) · Children and adults (no age limit) assessed for dental caries susceptibility · Case-control studies of children and adults (China, India, Czech Republic, Turkey), Ethnicity: Caucasian

Diagnostic accuracy for occlusal caries detection at the dentin caries detection level (D0-2 versus D3-4) · Human permanent posterior teeth (premolars and molars) in patients, occlusal (pit-and-fissure) surfaces · in vivo

Crossbite correction · Children and adults with a posterior crossbite, without a Class III skeletal relationship, cleft lip or palate (or… · Adolescents

Gingival index (GI) · Adolescents/teenagers undergoing orthodontic treatment · 18 months, Adolescents

Diagnostic accuracy for proximal caries detection (caries detection level) · Patients with permanent posterior teeth, proximal surfaces assessed clinically (in vivo) · In vivo (clinical); permanent posterior teeth, proximal surfaces, Caries detection level