Search review questions

Change in diastolic blood pressure (DBP, mmHg) · Adults (any age/sex) with chronic periodontitis (>=5 teeth remaining; PPD >4 mm), with or without hypertension · Long term (follow-up 12 months), People diagnosed with periodontitis

Childhood dental caries · Children in cross-sectional studies from Europe · Europe, Study region: Europe

Mean DMFT · Children aged 5-6 years in Ajman schools · Overall

Harms (toxicity and postoperative sensitivity) · People with permanent or adult posterior teeth requiring restoration (parallel-group trials involved children aged 6… · Follow-up: 2 weeks to 7 years

Sites with probing depth >= 4 mm · Adults (general and hospital populations assessed in case-control studies) · Hospital/clinic-based case-control studies from Asia, America and Europe

Specificity for detection and diagnosis of early (enamel) caries · Asymptomatic children, adolescents, or adults presenting for clinical examination (in vivo studies), or extracted… · Up to 3 months between index test and reference standard (in vivo studies), Proximal surfaces (CBCT)

Difference in sensitivity · Children or adults asymptomatic or suspected of enamel caries; extracted teeth · Clinical studies and in vitro extracted teeth, Analysis 1: fully within-person comparison

Dental caries susceptibility (risk of dental caries) · Children and adults (no age limit) assessed for dental caries susceptibility · Case-control studies of children and adults (China, India, Czech Republic, Turkey), Dentition: Mixed dentition caries

Diagnostic accuracy for proximal caries detection (dentin detection level) · Patients with permanent posterior teeth, proximal surfaces assessed clinically (in vivo) · In vivo (clinical); permanent posterior teeth, proximal surfaces, Dentin detection level

Sensitivity for detection and diagnosis of early (enamel) caries · Asymptomatic children, adolescents, or adults presenting for clinical examination (in vivo studies), or extracted… · Up to 3 months between index test and reference standard (in vivo studies), Dentine-caries (D3) prevalence medium 15-34% (non-CBCT)

Amount of crowding (change) up to 37 weeks · Children or adolescents (aged 16 years old or under) receiving orthodontic treatment to prevent or correct crowded teeth · up to 37 weeks

Sensitivity for detection of enamel/early caries · Children or adults presenting asymptomatically or suspected of having enamel caries (clinical/in vivo studies);… · Up to 3 months between index test and reference standard (in vivo; in vitro no limit if stored appropriately)

Plaque/gingivitis visible in at least one oral region · School children aged 11-17 years in Sharjah · Overall

Dental caries susceptibility (risk of dental caries) · Children and adults (no age limit) assessed for dental caries susceptibility · Case-control studies of children and adults (China, India, Czech Republic, Turkey), Dentition: Deciduous tooth decay

Dental caries susceptibility (risk of dental caries) · Children and adults (no age limit) assessed for dental caries susceptibility · Case-control studies of children and adults (China, India, Czech Republic, Turkey), Overall

Severe tooth wear prevalence · School children aged 2.6-6.8 years in Abu Dhabi · Overall

Specificity for detection of enamel caries · Asymptomatic children or adults presenting for clinical examination (in vivo studies), or extracted teeth of children… · Up to 3 months between index test and reference standard (in vivo studies), High prevalence of dentine caries (>= 35%)

Diagnostic accuracy for proximal caries detection (dentin detection level) · Extracted permanent posterior teeth with proximal surfaces (in vitro) · In vitro (laboratory; extracted teeth); permanent posterior teeth, proximal surfaces, Dentin detection level

Clinical attachment level (CAL) · Adults (any age/sex) with chronic periodontitis (>=5 teeth remaining; PPD >4 mm), with or without hypertension · Long term, People diagnosed with periodontitis and other cardiovascular diseases except hypertension

Dental caries susceptibility (risk of dental caries) · Children and adults (no age limit) assessed for dental caries susceptibility · Case-control studies of children and adults (China, India, Czech Republic, Turkey), Ethnicity: Caucasian

Water samples with fluoride concentration above the acceptable range

Outcome NR · Apparently healthy adults not reporting symptoms of OPMD or OSCC, attending an organised screening or surveillance…

Specificity for detection of oral cavity cancer/OPMD · Apparently healthy adults not reporting symptoms of OPMD or OSCC, attending an organised screening or surveillance…

Atherosclerotic cardiovascular disease (ACVD)-related events (morbidity and mortality) · Adults (any age) with a known number of remaining teeth, followed prospectively in cohort studies · Community-based and clinical cohorts worldwide (all continents); events ascertained from medical records, death certificates/registers, or self-report

Plaque index (PI) · Adults undergoing orthodontic treatment · 6 to 12 weeks, Adults

Dental caries prevalence · General population (children and adults) in East Africa · Community- and school-based populations, East Africa, Permanent dentition (>=12 years)

Caries (DMFT) and enamel defects · Preterm children (about 8 years old) in the United Arab Emirates (Dubai) · Dubai, UAE

Sensitivity · Children, adolescents, or adults presenting asymptomatically or suspected of early enamel caries (in vivo), or… · Up to 3 months between index test and reference standard (in vivo studies), Permanent dentition

Mean dmft · Preschool children in Sharjah day cares · Private day-care residents

Time to alignment (days) · Children or adolescents (aged 16 years old or under) receiving orthodontic treatment to prevent or correct crowded teeth · alignment

Changes in intensity of pain (VAS 0 to 10) tested through air blast stimuli · Patients aged above 12 years with self-reported tooth hypersensitivity confirmed on clinical evaluation · Long term (more than 2 months)

Peri-implant marginal bone level changes · Adults aged 18 years or older, in good general health (including well-controlled systemic disease), requiring… · 7 months

Amount of crowding · Children or adolescents (aged 16 years old or under) receiving orthodontic treatment to prevent or correct crowded teeth · 1 year

Proportion of participants diagnosed with hypertension at trial completion · Adults (any age/sex) with chronic periodontitis (>=5 teeth remaining; PPD >4 mm), with or without hypertension

Sensitivity for detection of oral cavity cancer/OPMD · Apparently healthy adults not reporting symptoms of OPMD or OSCC, attending an organised screening or surveillance…

Diagnostic accuracy for proximal caries detection (dentin detection level) · Extracted permanent posterior teeth with proximal surfaces (in vitro) · In vitro (laboratory; extracted teeth); permanent posterior teeth, proximal surfaces, Dentin detection level

Diagnostic accuracy for proximal caries detection (caries detection level) · Extracted permanent posterior teeth with proximal surfaces (in vitro) · In vitro (laboratory; extracted teeth); permanent posterior teeth, proximal surfaces, Caries detection level

Visible plaque and oral-hygiene behavior · Schoolchildren aged 4-6 years in the United Arab Emirates (Dubai) · 3 months, Dubai, UAE; private and governmental schools

Diagnostic accuracy for occlusal caries detection at the caries detection level (D0 versus D1-D4) · Human permanent posterior teeth (premolars and molars) in patients, occlusal (pit-and-fissure) surfaces · in vivo

Dental caries · Healthy children and adolescents in the United Arab Emirates · UAE; schools (Ajman, Sharjah), nurseries (Ras Al Khaimah)

Initiation of white spot lesions (WSL), visual-tactile assessment · Patients of any age (11-40 years) receiving comprehensive/fixed orthodontic treatment with fixed appliances · 3-27 months follow-up, Patients undergoing fixed (multibracket) orthodontic appliance treatment; clinical/dental setting; analysis at tooth level, Sealant with fluoride release

Changes in bucco-lingual/palatal width of alveolar ridge (mm) · Adults aged 18 years or older, in good general health (including well-controlled systemic disease), requiring… · 6 to 36 months

Specificity for detection and diagnosis of early (enamel) caries · Asymptomatic children, adolescents, or adults presenting for clinical examination (in vivo studies), or extracted… · Up to 3 months between index test and reference standard (in vivo studies), Permanent dentition (non-CBCT)

Mean DMFT · Children aged 5-6 years in Ajman schools · Overall

Aesthetic outcomes of future prosthodontic rehabilitation · Adults aged 18 years or older, in good general health (including well-controlled systemic disease), requiring… · 6 months

Diagnostic accuracy for proximal caries detection (dentin detection level) · Extracted permanent posterior teeth with proximal surfaces (in vitro) · In vitro (laboratory; extracted teeth); permanent posterior teeth, proximal surfaces, Dentin detection level

Changes in probing depth (PD) at teeth adjacent to the extraction site · Adults aged 18 years or older, in good general health (including well-controlled systemic disease), requiring… · 12 months

Diagnostic accuracy for occlusal caries detection at the dentin caries detection level (D0-2 versus D3-4) · Extracted human permanent posterior teeth (premolars and molars), occlusal (pit-and-fissure) surfaces · in vitro

Diagnostic accuracy for occlusal caries detection at the dentin caries detection level (D0-2 versus D3-4) · Extracted human permanent posterior teeth (premolars and molars), occlusal (pit-and-fissure) surfaces · in vitro

All-cause mortality (ACM) · Adults (any age) with a known number of remaining teeth, followed prospectively in cohort studies · Community-based and clinical cohorts worldwide (all continents); events ascertained from medical records, death certificates/registers, or self-report, Multivariable-adjusted