Search review questions

Specificity for detection of enamel/early caries · Children or adults presenting asymptomatically or suspected of having enamel caries (clinical/in vivo studies);… · Up to 3 months between index test and reference standard (in vivo; in vitro no limit if stored appropriately)

Specificity for detection and diagnosis of early (enamel) caries · Asymptomatic children, adolescents, or adults presenting for clinical examination (in vivo studies), or extracted… · Up to 3 months between index test and reference standard (in vivo studies)

Atherosclerotic cardiovascular disease (ACVD)-related events (morbidity and mortality) · Adults (any age) with a known number of remaining teeth, followed prospectively in cohort studies

Adverse events · Dental patients undergoing direct or indirect restorative treatment (no age or gender restriction) · treatment phase

Diagnostic accuracy for occlusal caries detection at the caries detection level (D0 versus D1-D4) · Extracted human permanent posterior teeth (premolars and molars), occlusal (pit-and-fissure) surfaces

Diagnostic accuracy for occlusal caries detection at the dentin caries detection level (D0-2 versus D3-4) · Human permanent posterior teeth (premolars and molars) in patients, occlusal (pit-and-fissure) surfaces

Sensitivity for detection and diagnosis of early (enamel) caries · Asymptomatic children, adolescents, or adults presenting for clinical examination (in vivo studies), or extracted… · Up to 3 months between index test and reference standard (in vivo studies), Occlusal surfaces (CBCT)

S. mutans presence (CFU > 10^5) · Adults undergoing orthodontic treatment · 6 months, Adults

Oral health status and treatment needs · Arab children with special healthcare needs in the United Arab Emirates (Ras Al Khaimah)

Diagnostic accuracy for proximal caries detection (caries detection level) · Extracted permanent posterior teeth with proximal surfaces (in vitro) · Caries detection level

Diagnostic accuracy for occlusal caries detection at the dentin caries detection level (D0-2 versus D3-4) · Human permanent posterior teeth (premolars and molars) in patients, occlusal (pit-and-fissure) surfaces

Oral health-related quality of life (child and family) · Preschool children in the United Arab Emirates receiving dental general anesthesia

Mean DMFT · School children aged 11-17 years in Sharjah · Overall

Costs: direct cost of treatment · Dental patients undergoing restorative treatment (no age or gender restriction)

Diagnostic accuracy for proximal caries detection (dentin detection level) · Extracted permanent posterior teeth with proximal surfaces (in vitro) · Dentin detection level

Mothers believing fluoride does not prevent tooth decay · Emirati preschool children in Ras Al Khaimah nurseries · Mothers of Emirati preschool children (Ras Al Khaimah)

Initiation of white spot lesions (WSL), visual-tactile assessment · Sensitivity (coating with vs without fluoride release, excluding parallel-arm studies)

Diagnostic accuracy for proximal caries detection (caries detection level) · Extracted permanent posterior teeth with proximal surfaces (in vitro) · Caries detection level

Diagnostic accuracy for proximal caries detection (dentin detection level) · Extracted permanent posterior teeth with proximal surfaces (in vitro) · Dentin detection level

Diagnostic accuracy for proximal caries detection (dentin detection level) · Patients with permanent posterior teeth, proximal surfaces assessed clinically (in vivo) · Dentin detection level

Initiation of white spot lesions (WSL), visual-tactile assessment · Sensitivity (sealant vs no sealant, excluding high risk-of-bias studies)

Mean dmft · Females (Gopinath)

Specificity for detection of enamel caries · Asymptomatic children or adults presenting for clinical examination (in vivo studies), or extracted teeth of children… · Up to 3 months between index test and reference standard (in vivo studies)

Initiation of white spot lesions (WSL), visual-tactile assessment · Patients of any age (11-40 years) receiving comprehensive/fixed orthodontic treatment with fixed appliances · 1-24 months follow-up, Resin-based sealants

Sensitivity for detection of enamel caries · Asymptomatic children or adults presenting for clinical examination (in vivo studies), or extracted teeth of children… · Up to 3 months between index test and reference standard (in vivo studies), Permanent dentition

Diagnostic accuracy for occlusal caries detection at the caries detection level (D0 versus D1-D4) · Human permanent posterior teeth (premolars and molars) in patients, occlusal (pit-and-fissure) surfaces

Dental caries · Children · Caries assessment: visual/tactile examination

Plaque prevalence · Preschool children of incarcerated mothers in UAE prison nurseries · Children of incarcerated mothers

Diagnostic accuracy for proximal caries detection (caries detection level) · Patients with permanent posterior teeth, proximal surfaces assessed clinically (in vivo) · Caries detection level

Utilization of dental services · Healthy Emirati preschool children in the United Arab Emirates

Dental caries susceptibility (risk of dental caries) · Children and adults (no age limit) assessed for dental caries susceptibility · Dentition: Deciduous tooth decay

Oral health status (caries, DMFT, calculus, erosion, malocclusion, treatment indices) · Children with Down syndrome in the United Arab Emirates (Dubai)

DMFT index · Adults (general and hospital populations assessed in case-control studies)

Outcome NR · Apparently healthy adults not reporting symptoms of OPMD or OSCC, attending an organised screening or surveillance…

Diagnostic accuracy for proximal caries detection (caries detection level) · Extracted permanent posterior teeth with proximal surfaces (in vitro) · Caries detection level

Diagnostic accuracy for proximal caries detection (caries detection level) · Extracted permanent posterior teeth with proximal surfaces (in vitro) · Caries detection level

Diagnostic accuracy for proximal caries detection (dentin detection level) · Extracted permanent posterior teeth with proximal surfaces (in vitro) · Dentin detection level

Dental caries prevalence · School children aged 5-7 years in Dubai schools · Overall

Dental erosion prevalence · Children with Down syndrome in Dubai · Children with Down syndrome

Childhood dental caries · Children in cross-sectional studies from Asia · Study region: Asia

Disease-free survival, concurrent chemoradiotherapy vs radiotherapy alone (pooled) · People receiving curative-intent treatment for oral cavity and oropharyngeal (squamous cell) cancer

Specificity for detection and diagnosis of early (enamel) caries · Asymptomatic children, adolescents, or adults presenting for clinical examination (in vivo studies), or extracted… · Up to 3 months between index test and reference standard (in vivo studies), Analogue and digital combined (non-CBCT); 97 datasets

Diagnostic accuracy for occlusal caries detection at the dentin caries detection level (D0-2 versus D3-4) · Extracted human permanent posterior teeth (premolars and molars), occlusal (pit-and-fissure) surfaces

Iron deficiency (ID) · Preschool children (<6 years) · Sensitivity analysis (Ramos-Gomez et al. 2002 excluded)

Optical/esthetic improvement (DIAGNOdent reading) · Patients (mainly children) with white spot lesions (WSL) · 3 to 6 months, Mild lesions, DIAGNOdent score <=14 (Ciftci et al. 2018; Giray et al. 2018)

Sensitivity for detection of enamel/early caries · Children or adults presenting asymptomatically or suspected of having enamel caries (clinical/in vivo studies);… · Up to 3 months between index test and reference standard (in vivo; in vitro no limit if stored appropriately)

Diagnostic accuracy for occlusal caries detection at the caries detection level (D0 versus D1-D4) · Extracted human permanent posterior teeth (premolars and molars), occlusal (pit-and-fissure) surfaces

Dental caries prevalence · General population (children and adults) in East Africa · Primary dentition

Radiographic proximal caries lesion progression · Patients with non-cavitated proximal (approximal) caries lesions (primary or permanent dentition) · Longest available follow-up, Caries risk: moderate

Fracture of restorations · People with permanent or adult posterior teeth requiring restoration (parallel-group trials involved children aged 6… · Follow-up: 5 to 7 years