Secondary caries · Patients requiring dental restoration; deciduous (primary) teeth
In deciduous teeth at 1 year, a single small trial found no difference in secondary caries between RMGIC and resin composite (RR 1.03, 95% CI 0.07-15.81; ungraded).
1 finding from 1 review
Future caries experience (dmft/dmfs) · Children younger than 6 years with caries-free primary dentition (no cavitated or non-cavitated lesions at baseline)
Children with mutans streptococci at baseline had a greater future caries experience (SMD 0.85, a large effect; ungraded).
1 finding from 1 review
Continued root formation / root development · Patients with carious pulp exposure in permanent teeth (predominantly immature) undergoing DPC or pulpotomy
Evidence on continued root formation for calcium hydroxide versus MTA is weak and inconclusive (3 RCTs, not pooled; ungraded).
1 finding from 1 review
Overall success (composite of clinical and radiographic success) · Patients with carious pulp exposure in permanent teeth with mixed root development
The effect of MTA versus CH in teeth with mixed root development is very uncertain (very low certainty).
1 finding from 1 review
Remineralization / reduction in lesion severity (change in QLF, laser fluorescence, or lesion area) · Patients with white spot lesions / early caries lesions (WSLs/ECLs), including orthodontic and non-orthodontic lesions, active caries…
P11-4 plus fluoride varnish did not differ significantly from P11-4 alone (SMD -0.40, 95% CI -0.97 to 0.17; indirect evidence only); certainty of evidence not assessed (no GRADE).
1 finding from 1 review
Secondary caries · Patients requiring dental restoration; permanent teeth
Over 2 or more years in permanent teeth, amalgam had a higher risk of secondary caries than GIC (RR 1.79, 95% CI 1.04-3.09; low certainty).
1 finding from 1 review
Cariogenic bacteria (Mutans streptococci) · Orthodontic patients (any age) undergoing orthodontic treatment (mostly fixed appliances)
Probiotic mouthwash has inconsistent effects on Mutans streptococci colony counts versus blank control; the evidence is very uncertain (very low certainty).
1 finding from 1 review
Salivary flow rate (unstimulated) · Elderly (>60 years) and medically compromised adults with xerostomia / dry mouth
codex
1 finding from 1 review
Poor oral health-related quality of life (OHRQoL) · Indians
Results were inconsistent and certainty was very low.
1 finding from 1 review
Remineralization / reduction in lesion severity (change in QLF, laser fluorescence, or lesion area) · Patients with white spot lesions / early caries lesions (WSLs/ECLs), including orthodontic and non-orthodontic lesions, active caries…
Fluoride varnish (gold standard) did not differ significantly from control (SMD -0.25, 95% CI -0.51 to 0.02); certainty of evidence not assessed (no GRADE).
1 finding from 1 review
Periapical pathosis incidence · Vital teeth
The pooled incidence with > 5–10 years of follow-up was 3.88%.
1 finding from 1 review
Gingival index (GI) · Orthodontic patients (any age) undergoing orthodontic treatment (mostly fixed appliances)
Chlorhexidine mouthwash probably reduces the Gingival Index versus placebo in the short term (WMD -0.45, 95% CI -0.70 to -0.20; low certainty).
1 finding from 1 review
Oral health-related quality of life · Indian elderly
Evidence on functional edentulism and OHRQoL is inconsistent across two studies (very low certainty).
2 findings from 1 review
Functional edentulism vs none: studies show inconsistency; one study found a significant association (Pushpanjali 2013), one did not (Shivakumar 2018); 368 participants, 2 observational studies; Very low certainty (Fig…
2 studies · 368 participants
Very low
SMD 0.31 [-0.37, 0.99]
4 studies · 1146 participants
Very low
CA VI concentration · Individuals assessed for dental caries (cases with caries/high caries vs. caries-free or low/very-low-caries controls)
CA VI concentration was lower in participants with caries (SMD -0.66, 95% CI -1.00 to -0.32; 2 studies, 141 participants); GRADE was not reported.
1 finding from 1 review
Pulp necrosis · Vital teeth
One study reported a 1.1% incidence with zinc polycarboxylate permanent cement.
1 finding from 1 review
Proportion 1.1
1 study
GRADE not reported
Remineralization / reduction in lesion severity (change in QLF, laser fluorescence, or lesion area) · Patients with white spot lesions / early caries lesions (WSLs/ECLs), including orthodontic and non-orthodontic lesions, active caries…
Self-assembling peptide P11-4 did not differ significantly from fluoride varnish (SMD -0.31, 95% CI -0.71 to 0.09); certainty of evidence not assessed (no GRADE).
1 finding from 1 review
Dental caries · Children (mixed dentition; baseline about 8 years)
In children with mixed dentition, vitamin D deficiency was associated with an 8% higher caries risk (RR 1.08; ungraded).
1 finding from 1 review
RR 1.08 [1.04, 1.12]
4 studies
GRADE not reported
Remineralization / reduction in lesion severity (change in QLF, laser fluorescence, or lesion area) · Patients with white spot lesions / early caries lesions (WSLs/ECLs), including orthodontic and non-orthodontic lesions, active caries…
Self-assembling peptide P11-4 did not differ significantly from CPP-ACP (SMD -0.38, 95% CI -0.87 to 0.11; indirect evidence only); certainty of evidence not assessed (no GRADE).
1 finding from 1 review
Remineralization / reduction in lesion severity (change in QLF, laser fluorescence, or lesion area) · Patients with white spot lesions / early caries lesions (WSLs/ECLs), including orthodontic and non-orthodontic lesions, active caries…
CPP-ACP did not differ significantly from CPP-ACFP (SMD 0.25, 95% CI -0.24 to 0.73); certainty of evidence not assessed (no GRADE).
1 finding from 1 review
Root caries (presence of root caries) · Adults (mean age ~53 years)
Adults with periodontal disease had significantly higher odds of root caries than those without (pooled OR 1.38, 95% CI 1.25 to 1.53; 2 observational studies; low certainty).
1 finding from 1 review