Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

3,288 questions · 3,354 findings · 516 reviews · Headline outcomes only

No studies found 720 · 21.5%GRADE not reported 164 · 4.9%Very low 950 · 28.3%Low 932 · 27.8%Moderate 434 · 12.9%High 154 · 4.6%

Early enteral nutrition vs delayed enteral nutrition

Feed intolerance or gastrointestinal complications (as defined by the authors) · critically ill adult patients

It is very uncertain whether early enteral nutrition changes feed intolerance or gastrointestinal complications (as defined by… compared with delayed enteral nutrition (very low certainty).

1 finding from 1 review

Natriuretic peptide‐guided treatment vs usual care

Ventricular dysfunction (as defined by trialists) · patients without heart failure

Natriuretic peptide‐guided treatment leads to lower ventricular dysfunction (as defined by trialists) compared with standard care (high certainty).

1 finding from 1 review

Perioperative beta‐blockers vs placebo or usual care

Ventricular arrhythmias (within 30 days) · adults undergoing non‐cardiac surgery under general anaesthesia (to include: low‐risk, medium‐risk, and high‐risk surgeries)

It is very uncertain whether perioperative beta‐blockers changes ventricular arrhythmias (within 30 days) compared with placebo or standard care (very low certainty).

1 finding from 1 review

Interventionist care vs expectant care

Intraventricular haemorrhage or hypoxic ischaemic encephalopathy · women with severe pre‐eclampsia between 24 and 34 weeks' gestation

Interventionist care probably leads to higher intraventricular haemorrhage or hypoxic ischaemic encephalopathy compared with expectant (delayed delivery) care (moderate certainty).

1 finding from 1 review

Beta‐blockers vs control—non‐cardiac surgery

Ventricular arrhythmias—non‐cardiac surgery ECG · patients with conditions requiring non‐cardiac surgery

Beta‐blocker showed no clear difference in ventricular arrhythmias—non‐cardiac surgery ECG compared with control—non‐cardiac surgery (moderate certainty).

1 finding from 1 review