Cochrane · systematic review · CD013015
Natriuretic peptide‐guided treatment for the prevention of cardiovascular events in patients without heart failure
Sweeney, C, Ryan, F, Ledwidge, M, et al. · Cochrane Database of Systematic Reviews · 2019 · Cochrane Library
HeartAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
6
current version
GRADE rated
6
No studies
0
Included studies
NR
No studies 0 · 0%Ungraded 0 · 0%Very low 0 · 0%Low 2 · 33.3%Moderate 3 · 50%High 1 · 16.7%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Natriuretic peptide‐guided treatment compared to standard care for the prevention of cardiovascular events in patients without heart failure
Population: patients without heart failure
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Cardiovascular mortality Natriuretic peptide‐guided treatment vs standard care | RR 0.33 [0.04, 3.17] | 1 study · 300 participants | Low Downgraded: imprecision |
Cardiovascular hospitalisation (as defined by trialists) Natriuretic peptide‐guided treatment vs standard care | RR 0.52 [0.4, 0.68] | 2 studies · 1674 participants | Moderate Downgraded: risk of bias, imprecision |
All‐cause mortality Natriuretic peptide‐guided treatment vs standard care | RR 0.9 [0.6, 1.35] | 2 studies · 1354 participants | Low Downgraded: risk of bias, imprecision |
All‐cause hospitalisation (all occurrences) Natriuretic peptide‐guided treatment vs standard care | RR 0.83 [0.75, 0.92] | 2 studies · 1354 participants | Moderate Downgraded: risk of bias, imprecision |
Ventricular dysfunction (as defined by trialists) Natriuretic peptide‐guided treatment vs standard care | RR 0.61 [0.41, 0.91] | 1 study · 1374 participants | High |
Change in NP level at the end of Natriuretic peptide‐guided treatment vs standard care | no estimate extracted | 1 study · 1374 participants | Moderate Downgraded: risk of bias, imprecision |