Cochrane · systematic review · CD004476
Perioperative beta‐blockers for preventing surgery‐related mortality and morbidity
Blessberger, H, Kammler, J, Domanovits, H, et al. · Cochrane Database of Systematic Reviews · 2018 · Cochrane Library
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
14
current version
GRADE rated
14
No studies
0
Included studies
NR
No studies 0 · 0%Ungraded 0 · 0%Very low 0 · 0%Low 5 · 35.7%Moderate 5 · 35.7%High 4 · 28.6%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Show all 2 versionsBeta‐blocker versus control—cardiac surgery
Population: patients with coronary heart disease and/or valvular heart disease
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
All‐cause mortality (30 days)—cardiac surgery Beta‐blocker vs control—cardiac surgery | RR 0.73 [0.35, 1.52] | 24 studies · 3783 participants | Moderate Downgraded: imprecision |
Acute myocardial infarction—cardiac surgery Beta‐blocker vs control—cardiac surgery | RR 1.04 [0.71, 1.51] | 22 studies · 3553 participants | Moderate Downgraded: imprecision |
Cerebrovascular events—cardiac surgery Beta‐blocker vs control—cardiac surgery | RR 1.52 [0.58, 4.02] | 4 studies · 1400 participants | Low Downgraded: imprecision, publication bias |
Ventricular arrhythmias—cardiac surgery ECG Beta‐blocker vs control—cardiac surgery | RR 0.37 [0.24, 0.58] | 12 studies · 2292 participants | Moderate Downgraded: imprecision, publication bias |
All supraventricular arrhythmias—cardiac surgery ECG Beta‐blocker vs control—cardiac surgery | RR 0.44 [0.36, 0.53] | 48 studies · 6420 participants | High |
Bradycardia—cardiac surgery ECG Beta‐blocker vs control—cardiac surgery | RR 1.61 [0.97, 2.66] | 8 studies · 660 participants | Low Downgraded: imprecision, publication bias |
Hypotension—cardiac surgery Beta‐blocker vs control—cardiac surgery | RR 1.54 [0.67, 3.51] | 6 studies · 558 participants | Low Downgraded: imprecision, publication bias |
Beta‐blocker versus control—non‐cardiac surgery
Population: patients with conditions requiring non‐cardiac surgery
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
All‐cause mortality (30 days)—non‐cardiac surgery Beta‐blocker vs control—non‐cardiac surgery | RR 1.25 [1, 1.57] | 13 studies · 11413 participants | Low Downgraded: imprecision |
Acute myocardial infarction—non‐cardiac surgery Beta‐blocker vs control—non‐cardiac surgery | RR 0.73 [0.61, 0.87] | 14 studies · 10958 participants | High |
Cerebrovascular events—non‐cardiac surgery Beta‐blocker vs control—non‐cardiac surgery | RR 1.59 [0.93, 2.71] | 5 studies · 9150 participants | Low Downgraded: risk of bias, imprecision, inconsistency |
Ventricular arrhythmias—non‐cardiac surgery ECG Beta‐blocker vs control—non‐cardiac surgery | RR 0.68 [0.31, 1.49] | 5 studies · 476 participants | Moderate Downgraded: risk of bias, imprecision, inconsistency |
All supraventricular arrhythmias—non‐cardiac surgery ECG Beta‐blocker vs control—non‐cardiac surgery | RR 0.73 [0.57, 0.94] | 8 studies · 8744 participants | High |
Bradycardia—non‐cardiac surgery ECG Beta‐blocker vs control—non‐cardiac surgery | RR 2.23 [1.48, 3.36] | 23 studies · 11033 participants | Moderate Downgraded: risk of bias, imprecision, inconsistency |
Hypotension—non‐cardiac surgery Beta‐blocker vs control—non‐cardiac surgery | RR 1.5 [1.38, 1.64] | 22 studies · 10947 participants | High |