Cochrane · systematic review · CD011780
Equivalent schedules of intradermal fractional dose versus intramuscular full dose of inactivated polio vaccine for prevention of poliomyelitis
Jaiswal, N, Singh, S, Agarwal, A, et al. · Cochrane Database of Systematic Reviews · 2019 · Cochrane Library
Developmental, Psychosocial and Learning ProblemsAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
6
current version
GRADE rated
5
No studies
1
Included studies
NR
No studies 1 · 16.7%Ungraded 0 · 0%Very low 3 · 50%Low 2 · 33.3%Moderate 0 · 0%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Equivalent schedules of intradermal fractional‐dose inactivated poliovirus vaccine compared to intramuscular inactivated poliovirus vaccine for the prevention of poliomyelitis in children
Population: children
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Paralytic poliomyelitis (not measured) Equivalent schedules of intradermal fractional‐dose inactivated poliovirus vaccine vs intramuscular inactivated poliovirus vaccine | no estimate extracted | NR | No studies |
Seroconversion rate (after a single primary dose) Equivalent schedules of intradermal fractional‐dose inactivated poliovirus vaccine vs intramuscular inactivated poliovirus vaccine | OR 0.3 [0.22, 0.41] | 6 studies · 2570 participants | Low Downgraded: risk of bias, imprecision, indirectness |
Seroconversion rate (after 2 primary doses) Equivalent schedules of intradermal fractional‐dose inactivated poliovirus vaccine vs intramuscular inactivated poliovirus vaccine | OR 0.23 [0.16, 0.33] | 3 studies · 981 participants | Low Downgraded: risk of bias, indirectness |
Seroconversion rate (after 3 primary doses) Equivalent schedules of intradermal fractional‐dose inactivated poliovirus vaccine vs intramuscular inactivated poliovirus vaccine | OR 0.45 [0.07, 3.15] | 3 studies · 973 participants | Very low Downgraded: risk of bias, inconsistency, indirectness |
Geometric mean titres Equivalent schedules of intradermal fractional‐dose inactivated poliovirus vaccine vs intramuscular inactivated poliovirus vaccine | no estimate extracted | 7 studies · 4887 participants | Very low Downgraded: risk of bias, inconsistency, indirectness |
Vaccine‐related adverse events Equivalent schedules of intradermal fractional‐dose inactivated poliovirus vaccine vs intramuscular inactivated poliovirus vaccine | no estimate extracted | 7 studies · 4121 participants | Very low Downgraded: risk of bias, imprecision, inconsistency, indirectness |