Cochrane · systematic review · CD000542
Enteral nutritional therapy for induction of remission in Crohn's disease
Narula, N, Dhillon, A, Zhang, D, et al. · Cochrane Database of Systematic Reviews · 2018 · Cochrane Library
GutAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
9
current version
GRADE rated
9
No studies
0
Included studies
NR
No studies 0 · 0%Ungraded 0 · 0%Very low 9 · 100%Low 0 · 0%Moderate 0 · 0%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Elemental compared to non‐elemental enteral feeds for induction of remission in Crohn's disease
Population: induction of remission in Crohn's disease
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Remission rate ‐ Intention to treat Elemental vs non‐elemental enteral feeds | RR 1.02 [0.88, 1.18] | 11 studies · 378 participants | Very low Downgraded: risk of bias |
Adverse events Elemental vs non‐elemental enteral feeds | RR 1.01 [0.62, 1.65] | 9 studies · 323 participants | Very low Downgraded: risk of bias, imprecision |
Withdrawal due to adverse events Elemental vs non‐elemental enteral feeds | RR 1.37 [0.83, 2.25] | 7 studies · 272 participants | Very low Downgraded: risk of bias, imprecision |
Enteral nutrition compared to corticosteroids for induction of remission in Crohn's disease
Population: induction of remission in Crohn's disease
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Remission rate ‐ ITT Enteral nutrition vs corticosteroids | RR 0.77 [0.58, 1.03] | 8 studies · 409 participants | Very low Downgraded: risk of bias |
Remission rate ‐ ITT adult studies Enteral nutrition vs corticosteroids | RR 0.65 [0.52, 0.82] | 6 studies · 352 participants | Very low Downgraded: risk of bias, imprecision, inconsistency |
Remission rate ‐ ITT pediatric studies Enteral nutrition vs corticosteroids | RR 1.35 [0.92, 1.97] | 2 studies · 57 participants | Very low Downgraded: risk of bias, imprecision, inconsistency |
Remission rate ‐ per‐protocol ‐ pediatric studies Enteral nutrition vs corticosteroids | RR 1.43 [1.03, 1.97] | 2 studies · 55 participants | Very low Downgraded: risk of bias, imprecision, inconsistency |
Adverse events Enteral nutrition vs corticosteroids | RR 1.39 [0.62, 3.11] | 7 studies · 389 participants | Very low Downgraded: risk of bias, imprecision, inconsistency |
Withdrawal due to adverse events Enteral nutrition vs corticosteroids | RR 2.95 [1.02, 8.48] | 3 studies · 169 participants | Very low Downgraded: risk of bias, imprecision, inconsistency |