Cochrane · systematic review · CD013435
Perioperative beta‐blockers for preventing surgery‐related mortality and morbidity in adults undergoing cardiac surgery
Blessberger, H, Lewis, SR, Pritchard, MW, et al. · Cochrane Database of Systematic Reviews · 2019 · Cochrane Library
AnaesthesiaAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
7
current version
GRADE rated
7
No studies
0
Included studies
NR
No studies 0 · 0%Ungraded 0 · 0%Very low 1 · 14.3%Low 6 · 85.7%Moderate 0 · 0%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Perioperative beta‐blockers for preventing surgery‐related mortality and morbidity in adults undergoing cardiac surgery
Population: adults undergoing cardiac surgery under general anaesthesia
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
All‐cause mortality (within 30 days) | RR 0.95 [0.47, 1.9] | 29 studies · 4099 participants | Low Downgraded: risk of bias, imprecision |
Acute myocardial infarction (within 30 days) | RR 1.05 [0.72, 1.52] | 25 studies · 3946 participants | Low Downgraded: risk of bias, imprecision |
Cerebrovascular events (within 30 days) | RR 1.37 | 5 studies · 1471 participants | Very low Downgraded: risk of bias, imprecision |
Ventricular arrhythmias (within 30 days) | RR 0.4 [0.25, 0.63] | 12 studies · 2296 participants | Low Downgraded: risk of bias, imprecision |
Atrial fibrillation or flutter, or both (within 30 days) | RR 0.5 [0.42, 0.59] | 40 studies · 5650 participants | Low Downgraded: risk of bias, inconsistency |
Bradycardia (within 30 days; as defined by study authors, minimum heart rate < 60 beats per minute or requiring medication) | RR 1.63 [0.92, 2.91] | 12 studies · 1640 participants | Low Downgraded: risk of bias, imprecision |
Hypotension (within 30 days; as defined by study authors, minimum systolic blood pressure < 90 mmHg or requiring medication) | RR 1.84 [0.89, 3.8] | 10 studies · 1538 participants | Low Downgraded: risk of bias, imprecision |