Cochrane · systematic review · CD012839
Dietary interventions for induction and maintenance of remission in inflammatory bowel disease
Limketkai, BN, Iheozor‐Ejiofor, Z, Gjuladin‐Hellon, T, et al. · Cochrane Database of Systematic Reviews · 2019 · Cochrane Library
GutAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
22
current version
GRADE rated
16
No studies
6
Included studies
NR
No studies 6 · 27.3%Ungraded 0 · 0%Very low 11 · 50%Low 5 · 22.7%Moderate 0 · 0%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Intervention diet compared to control diet for induction of remission in active Crohn's disease
Population: people with active Crohn's disease
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Induction of remission at 4 weeks ‐ High‐fiber, low refined carbohydrates diet Intervention diet vs control diet | RR 7.2 [0.53, 97.83] | 1 study · 7 participants | Very low Downgraded: risk of bias |
Induction of remission at 16 weeks ‐ Low microparticle diet Intervention diet vs control diet | RR 3.13 [0.22, 43.84] | 2 studies · 103 participants | Very low Downgraded: risk of bias |
Induction of remission at 16 weeks ‐ Low calcium diet Intervention diet vs control diet | RR 1.24 [0.67, 2.29] | 1 study · 83 participants | Very low Downgraded: risk of bias |
Induction of remission (timeframe not reported) ‐ Symptoms‐guided diet Intervention diet vs control diet | RR 20 [1.27, 315.4] | 1 study · 51 participants | Very low Downgraded: risk of bias |
Induction of remission at 6 weeks ‐ Highly restricted, organic diet Intervention diet vs control diet | RR 1 [0.39, 2.53] | 1 study · 18 participants | Very low Downgraded: risk of bias |
Health‐related quality of life (timeframe not reported) ‐ IBDQ ‐ Symptoms‐guided diet Intervention diet vs control diet | no estimate extracted | 1 study · 51 participants | Low Downgraded: risk of bias |
Health‐related quality of life at 6 weeks ‐ IBDQ ‐ Highly restricted, organic diet Intervention diet vs control diet | no estimate extracted | 1 study · 14 participants | Very low Downgraded: risk of bias |
Adverse events Intervention diet vs control diet | no estimate extracted | NR | No studies |
Intervention diet compared to control diet for maintenance of remission in inactive Crohn's disease
Population: people with inactive Crohn's disease
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Clinical relapse at 12 to 24 months ‐ Low refined carbohydrate diet Intervention diet vs control diet | RR 1.04 [0.87, 1.25] | 3 studies · 567 participants | Low Downgraded: risk of bias |
Clinical relapse at 6 to 24 months ‐ Symptoms‐guided diet Intervention diet vs control diet | RR 0.53 [0.28, 1.01] | 2 studies · 98 participants | Low Downgraded: risk of bias |
Clinical relapse at 48 weeks ‐ Low red, processed meat diet Intervention diet vs control diet | RR 1.03 [0.85, 1.26] | 1 study · 214 participants | Low Downgraded: risk of bias |
Clinical relapse at 12 months ‐ Exclusion diets (low disaccharides, grains, saturated fats, red and processed meats) Intervention diet vs control diet | RR 0.11 [0.01, 1.76] | 1 study · 54 participants | Very low Downgraded: risk of bias |
Health‐related quality of life Intervention diet vs control diet | no estimate extracted | NR | No studies |
Adverse events Intervention diet vs control diet | no estimate extracted | NR | No studies |
Intervention diet compared to control diet for induction of remission in active ulcerative colitis
Population: people with active ulcerative colitis
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Induction of remission ‐ Symptoms‐guided diet Intervention diet vs control diet | RR 8.25 [0.5, 136.33] | 1 study · 21 participants | Very low Downgraded: risk of bias |
Health‐related quality of life Intervention diet vs control diet | no estimate extracted | NR | No studies |
Adverse events Intervention diet vs control diet | no estimate extracted | NR | No studies |
Intervention diet compared to control diet for maintenance of remission in inactive ulcerative colitis
Population: Participants with inactive ulcerative colitis
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Clinical relapse at 6 months ‐ Anti‐inflammatory diet (Alberta‐based) Intervention diet vs control diet | RR 1.25 [0.42, 3.7] | 1 study · 28 participants | Very low Downgraded: risk of bias |
Clinical relapse at 12 months ‐ Carrageenan‐free diet Intervention diet vs control diet | RR 0.5 [0.15, 1.64] | 1 study · 15 participants | Very low Downgraded: risk of bias |
Clinical relapse at 12 months ‐ Milk free diet Intervention diet vs control diet | RR 0.83 [0.6, 1.15] | 2 studies · 77 participants | Low Downgraded: risk of bias |
Health related quality of life at 12 months ‐ SIBDQ ‐ Carrageenan‐free diet Intervention diet vs control diet | no estimate extracted | 1 study · 12 participants | Very low Downgraded: risk of bias |
Adverse events Intervention diet vs control diet | no estimate extracted | NR | No studies |