Cochrane · systematic review · CD011688
Fluoxetine for adults who are overweight or obese
Serralde-Zúñiga, AE, Gonzalez Garay, AG, Rodríguez-Carmona, Y, et al. · Cochrane Database of Systematic Reviews · 2019 · Cochrane Library
Metabolic and Endocrine DisordersAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
7
current version
GRADE rated
4
No studies
3
Included studies
NR
No studies 3 · 42.9%Ungraded 0 · 0%Very low 3 · 42.9%Low 1 · 14.3%Moderate 0 · 0%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Summary of findings: fluoxetine compared with placebo
Population: overweight or obese adults
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Weight loss (kg) (a) All fluoxetine dosages (b) Fluoxetine 60 mg/d(c) Fluoxetine 40 mg/d(d) Fluoxetine 20 mg/d Summary of findings: fluoxetine vs placebo | no estimate extracted | 10 studies · 956 participants | Very low Downgraded: risk of bias, imprecision, inconsistency |
Health‐related quality of life Summary of findings: fluoxetine vs placebo | no estimate extracted | NR | No studies |
Any adverse event (N) Summary of findings: fluoxetine vs placebo | RR 1.18 [0.99, 1.42] | 9 studies · 1253 participants | Low Downgraded: risk of bias, imprecision |
Anthropometric measurements other than weight loss in kg (BMI reduction measured inkg/m²) Summary of findings: fluoxetine vs placebo | no estimate extracted | 3 studies · 97 participants | Very low Downgraded: risk of bias, imprecision |
Morbidity: depression (N) Summary of findings: fluoxetine vs placebo | RR 1.2 [0.57, 2.52] | 3 studies · 393 participants | Very low Downgraded: risk of bias, imprecision |
All‐cause mortality Summary of findings: fluoxetine vs placebo | no estimate extracted | NR | No studies |
Socioeconomic effects Summary of findings: fluoxetine vs placebo | no estimate extracted | NR | No studies |