Findings

What do systematic reviews say?

Refine by population, intervention, comparison or outcome
More filters
Evidence found and GRADE certainty

2,123 questions · 2,188 findings · 243 reviews

No studies found 493 · 22.5%GRADE not reported 160 · 7.3%Very low 600 · 27.4%Low 474 · 21.7%Moderate 364 · 16.6%High 97 · 4.4%

Fixed‐dose combination aclidinium/formoterol vs aclidinium alone

Exacerbations requiring steroids or antibiotics or both: number of participants · patients with chronic obstructive pulmonary disease

Fixed‐dose combination aclidinium/formoterol showed no clear difference in exacerbations requiring steroids or antibiotics or both: number of… compared with aclidinium alone (moderate certainty).

1 finding from 1 review

Fixed‐dose combination aclidinium/formoterol vs placebo

Exacerbations requiring steroids or antibiotics or both: number of participants · patients with chronic obstructive pulmonary disease

Fixed‐dose combination aclidinium/formoterol showed no clear difference in exacerbations requiring steroids or antibiotics or both: number of… compared with placebo (moderate certainty).

1 finding from 1 review

Fixed‐dose combination aclidinium/formoterol vs formoterol

Exacerbations requiring steroids or antibiotics or both: number of participants · patients with chronic obstructive pulmonary disease

Fixed‐dose combination aclidinium/formoterol leads to lower exacerbations requiring steroids or antibiotics or both: number of… compared with formoterol (high certainty).

1 finding from 1 review

Once‐daily ICS/LABA combined inhalers vs once‐daily LAMA

Any COPD exacerbation that requires short‐burst oral corticosteroids or antibiotics, or both · patients with chronic obstructive pulmonary disease

It is very uncertain whether once‐daily ICS/LABA combined inhalers changes any COPD exacerbation that requires short‐burst oral corticosteroids… compared with once‐daily LAMA (very low certainty).

1 finding from 1 review

Intervention not reported

Antibiotic prescriptions (number of courses/person/year) **Corticosteroids not meta‐analysed · adults (> 18 years of age) with either COPD or recurrent acute exacerbations of chronic bronchitis

The intervention may leads to higher antibiotic prescriptions (number of courses/person/year)… (low certainty).

1 finding from 1 review

Umeclidinium bromide vs placebo

Exacerbations requiring steroids or antibiotics or both: number of participants · patients with chronic obstructive pulmonary disease

Umeclidinium bromide leads to lower number of participants with exacerbations requiring steroids,… compared with placebo (high certainty).

1 finding from 1 review

Xylitol vs control

Antibiotic administration · preventing acute otitis media in children up to 12 years of age

Xylitol showed no clear difference in antibiotic administration compared with control (moderate certainty).

2 findings from 1 review

Normal saline plus standard treatment vs usual care

Antibiotic usage Patient‐reported usage · patients with acute upper respiratory tract infections

It is very uncertain whether normal saline plus standard treatment changes antibiotic usage Patient‐reported usage compared with standard treatment alone (very low certainty).

1 finding from 1 review

Intervention not reported

Symptomatic bacterial UTI in women with recent UTI Probiotics versus antibiotics ( · adults and children at risk of UTI

The intervention showed no clear difference in symptomatic bacterial UTI in women with recent UTI Probiotics versus… (low certainty).

1 finding from 1 review