Cochrane · systematic review · CD011897
Umeclidinium bromide versus placebo for people with chronic obstructive pulmonary disease (COPD)
Ni, H, Htet, A, Moe, S · Cochrane Database of Systematic Reviews · 2017 · Cochrane Library
AirwaysAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
7
current version
GRADE rated
7
No studies
0
Included studies
NR
No studies 0 · 0%Ungraded 0 · 0%Very low 0 · 0%Low 1 · 14.3%Moderate 3 · 42.9%High 3 · 42.9%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Umeclidinium bromide compared with placebo for stable chronic obstructive pulmonary disease
Population: people with chronic obstructive pulmonary disease (COPD)
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Number of participants with exacerbations requiring steroids, antibiotics, or both Umeclidinium bromide vs placebo | OR 0.61 [0.46, 0.8] | 4 studies · 1922 participants | High |
Quality of life: number of participants with ≥ 4 units improvement in SGRQ total score Umeclidinium bromide vs placebo | OR 1.45 [1.16, 1.82] | 3 studies · 1397 participants | Moderate Downgraded: inconsistency |
Non‐fatal serious adverse events Umeclidinium bromide vs placebo | OR 1.33 [0.89, 2] | 4 studies · 1922 participants | Moderate Downgraded: imprecision, inconsistency |
Number of participants with hospital admissions due to COPD exacerbation Umeclidinium bromide vs placebo | OR 0.86 [0.25, 2.92] | 4 studies · 1922 participants | Low Downgraded: imprecision, inconsistency |
Number of participants with ≥ 1 unit improvement in TDI focal score Umeclidinium bromide vs placebo | OR 1.71 [1.37, 2.15] | 3 studies · 1441 participants | High |
Change from baseline in trough FEV1 (L) Umeclidinium bromide vs placebo | no estimate extracted | 4 studies · 1381 participants | High |
Adverse events (not including serious adverse events) Umeclidinium bromide vs placebo | OR 1.06 [0.85, 1.31] | 4 studies · 1922 participants | Moderate Downgraded: imprecision, inconsistency |