Cochrane · systematic review · CD012355
Once‐daily long‐acting beta₂‐agonists/inhaled corticosteroids combined inhalers versus inhaled long‐acting muscarinic antagonists for people with chronic obstructive pulmonary disease
Sliwka, A, Jankowski, M, Gross‐Sondej, I, et al. · Cochrane Database of Systematic Reviews · 2018 · Cochrane Library
AirwaysAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
7
current version
GRADE rated
5
No studies
2
Included studies
NR
No studies 2 · 28.6%Ungraded 0 · 0%Very low 5 · 71.4%Low 0 · 0%Moderate 0 · 0%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Once‐daily ICS/LABA combined inhalers compared to once‐daily LAMA for people with chronic obstructive pulmonary disease
Population: people with chronic obstructive pulmonary disease
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Mortality (all‐cause) Once‐daily ICS/LABA combined inhalers vs once‐daily LAMA | OR 0.2 [0.02, 1.73] | 2 studies · 880 participants | Very low Downgraded: risk of bias, imprecision |
Any COPD exacerbation that requires short‐burst oral corticosteroids or antibiotics, or both Once‐daily ICS/LABA combined inhalers vs once‐daily LAMA | OR 0.72 [0.35, 1.5] | 2 studies · 880 participants | Very low Downgraded: risk of bias, imprecision |
Pneumonia Once‐daily ICS/LABA combined inhalers vs once‐daily LAMA | OR 6.12 [0.73, 51.24] | 2 studies · 880 participants | Very low Downgraded: risk of bias, imprecision |
Quality of life Once‐daily ICS/LABA combined inhalers vs once‐daily LAMA | no estimate extracted | 2 studies · 779 participants | Very low Downgraded: risk of bias, imprecision |
Hospital admissions (all‐cause) Once‐daily ICS/LABA combined inhalers vs once‐daily LAMA | OR 0.96 [0.49, 1.89] | 2 studies · 880 participants | Very low Downgraded: risk of bias, imprecision |
Exacerbations leading to intubation Once‐daily ICS/LABA combined inhalers vs once‐daily LAMA | no estimate extracted | NR | No studies |
Physical activity measure (e.g. 6MWT) Once‐daily ICS/LABA combined inhalers vs once‐daily LAMA | no estimate extracted | NR | No studies |