Cochrane · systematic review · CD005339
Granulocyte transfusions for treating infections in people with neutropenia or neutrophil dysfunction
Estcourt, LJ, Stanworth, SJ, Hopewell, S, et al. · Cochrane Database of Systematic Reviews · 2016 · Cochrane Library
Gynaecological, Neuro-oncology and Orphan CancerAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
7
current version
GRADE rated
3
No studies
4
Included studies
NR
No studies 4 · 57.1%Ungraded 0 · 0%Very low 2 · 28.6%Low 1 · 14.3%Moderate 0 · 0%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Comparison
Population: treating infections in people with neutropenia or neutrophil dysfunction
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Overall mortality | RR 0.75 [0.54, 1.04] | 6 studies · 321 participants | Very low |
Clinical response to infection | RR 0.98 [0.81, 1.19] | 5 studies · 286 participants | Low Downgraded: risk of bias, imprecision |
Length of time with fever ‐ not reported | no estimate extracted | NR | No studies |
Number of days on therapeutic antibiotics ‐ not reported | no estimate extracted | NR | No studies |
Number of serious adverse events ‐ pulmonary | RR 0.85 [0.38, 1.88] | 1 study · 24 participants | Very low Downgraded: risk of bias, imprecision |
Number of adverse events requiring discontinuation of treatment ‐ not reported | no estimate extracted | NR | No studies |
Quality of life ‐ not reported | no estimate extracted | NR | No studies |