Cochrane · systematic review · CD010089

Influenza vaccines for preventing acute otitis media in infants and children

Norhayati, MN, Ho, JJ, Azman, MY · Cochrane Database of Systematic Reviews · 2017 · Cochrane Library

Acute Respiratory Infections2 versionsAMSTAR 2: not assessed

SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.

Questions

current version

GRADE rated

No studies

Included studies

No studies 0 · 0%Ungraded 0 · 0%Very low 0 · 0%Low 4 · 80%Moderate 1 · 20%High 0 · 0%

Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.

Questions and results

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Influenza vaccine compared to control for preventing acute otitis media in infants and children

Population: infants and children

5 questions

Outcome	Effect	Evidence	Status / GRADE
At least 1 episode of acute otitis media Influenza vaccine vs control	RR 0.84 [0.69, 1.02]	4 studies · 3134 participants	Low Downgraded: risk of bias, inconsistency, publication bias
Courses of antibiotics Influenza vaccine vs control	RR 0.7 [0.59, 0.83]	2 studies · 1223 participants	Moderate Downgraded: risk of bias, publication bias
Fever Influenza vaccine vs control	RR 1.15 [1.06, 1.24]	7 studies · 10615 participants	Low Downgraded: risk of bias, inconsistency, publication bias
Rhinorrhoea Influenza vaccine vs control	RR 1.17 [1.07, 1.29]	6 studies · 10563 participants	Low Downgraded: risk of bias, inconsistency, publication bias
Pharyngitis Influenza vaccine vs control	RR 1 [0.8, 1.25]	3 studies · 4429 participants	Low Downgraded: risk of bias, inconsistency, publication bias