Cochrane · systematic review · CD010089
Influenza vaccines for preventing acute otitis media in infants and children
Norhayati, MN, Ho, JJ, Azman, MY · Cochrane Database of Systematic Reviews · 2017 · Cochrane Library
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
5
current version
GRADE rated
5
No studies
0
Included studies
NR
No studies 0 · 0%Ungraded 0 · 0%Very low 0 · 0%Low 4 · 80%Moderate 1 · 20%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Current version onlyInfluenza vaccine compared to control for preventing acute otitis media in infants and children
Population: infants and children
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
At least 1 episode of acute otitis media Influenza vaccine vs control | RR 0.84 [0.69, 1.02] | 4 studies · 3134 participants | Low Downgraded: risk of bias, inconsistency, publication bias |
Courses of antibiotics Influenza vaccine vs control | RR 0.7 [0.59, 0.83] | 2 studies · 1223 participants | Moderate Downgraded: risk of bias, publication bias |
Fever Influenza vaccine vs control | RR 1.15 [1.06, 1.24] | 7 studies · 10615 participants | Low Downgraded: risk of bias, inconsistency, publication bias |
Rhinorrhoea Influenza vaccine vs control | RR 1.17 [1.07, 1.29] | 6 studies · 10563 participants | Low Downgraded: risk of bias, inconsistency, publication bias |
Pharyngitis Influenza vaccine vs control | RR 1 [0.8, 1.25] | 3 studies · 4429 participants | Low Downgraded: risk of bias, inconsistency, publication bias |
Influenza vaccine compared to control for preventing acute otitis media
Population: infants and children
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
At least one episode of AOM Influenza vaccine vs control | RR 0.8 [0.67, 0.96] | 5 studies · 4736 participants | High |
AOM by setting ‐ healthcare setting Influenza vaccine vs control | RR 0.84 [0.71, 0.99] | 4 studies · 4550 participants | High |
AOM by setting ‐ daycare setting Influenza vaccine vs control | RR 0.58 [0.36, 0.92] | 1 study · 186 participants | Moderate Downgraded: imprecision |
Courses of antibiotics Influenza vaccine vs control | RR 0.7 [0.59, 0.83] | 2 studies · 1223 participants | High |
Adverse event ‐ fever Influenza vaccine vs control | RR 1.15 [1.06, 1.24] | 6 studies · 10199 participants | Moderate Downgraded: risk of bias, imprecision |
Adverse event ‐ rhinorrhoea Influenza vaccine vs control | RR 1.17 [1.07, 1.29] | 6 studies · 10563 participants | Moderate Downgraded: risk of bias, imprecision |
Adverse event ‐ pharyngitis Influenza vaccine vs control | RR 1 [0.8, 1.25] | 3 studies · 4429 participants | Moderate Downgraded: risk of bias, imprecision |