Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

1,692 questions · 2,586 findings · 180 reviews · Dental caries

No studies found 194 · 7.5%GRADE not reported 1,937 · 74.9%Very low 248 · 9.6%Low 136 · 5.3%Moderate 52 · 2%High 19 · 0.7%

Prenatal vitamin D level ≤50 nmol/L vs Adequate prenatal vitamin D (sufficient maternal 25(OH)D)

Dental caries · Children aged 2 to 8 years

The review reported a lower odds ratio at maternal prenatal vitamin D ≤50 nmol/L than at ≤35 nmol/L, without a numeric value in the available sources.

1 finding from 1 review

Prenatal vitamin D level ≤35 nmol/L vs Adequate prenatal vitamin D (sufficient maternal 25(OH)D)

Dental caries · Children aged 2 to 8 years

The review reported a slightly higher odds ratio at maternal prenatal vitamin D ≤35 nmol/L than at ≤50 nmol/L, without a numeric value in the available sources.

1 finding from 1 review

Preterm birth (<37 weeks gestation) vs Full-term birth (37 weeks or more gestation)

Early childhood caries (ECC) · Children aged 6 years or younger (preschool children)

In children aged 3 years or younger, preterm birth was not associated with early childhood caries (OR 0.90, 95% CI 0.59 to 1.37); certainty not graded.

2 findings from 1 review

Prenatal vitamin D deficiency (low maternal 25(OH)D during pregnancy) vs Adequate prenatal vitamin D (sufficient maternal 25(OH)D)

Dental caries · Children aged 2 to 8 years

The review reported an OR of 1.32 when prenatal vitamin D was measured at 6 to 38 gestational weeks.

2 findings from 1 review

Multivariable caries prediction model vs Additional prediction model(s)

Coronal caries increment · Individuals of all ages

The review reported this model performance without meta-analysis.

168 findings from 1 review
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Multivariable caries prediction model vs Additional prediction model(s)

Root caries increment · Individuals of all ages

The review reported this model performance without meta-analysis.

22 findings from 1 review
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Multivariable caries prediction model vs Additional prediction model(s)

Coronal and/or root caries increment · Individuals of all ages

The review reported this model performance without meta-analysis.

2 findings from 1 review

Laser enamel preparation (with or without acid-etching) vs Acid-etching (phosphoric acid)

Adverse events · Caries-free children to young adults with premolars/molars requiring pit-and-fissure sealants

No adverse events were reported in any included study (ungraded, narrative).

1 finding from 1 review

Preformed metal crown (fitted using the Hall Technique) vs Preformed metal crown (fitted using a conventional technique)

Outcome not reported · Children with decayed primary molar teeth

The review found no eligible studies for this question.

1 finding from 1 review
  • None of the included studies compared the effectiveness or safety of the Hall Technique versus the conventional technique of fitting a crown. No RCT evidence found.
    0 studies
    No studies found

Laser enamel preparation alone (Er,Cr:YSGG or CO2 laser) vs Acid-etching (phosphoric acid)

Development of >=1 new carious lesion (caries incidence) · Caries-free children to young adults with premolars/molars requiring pit-and-fissure sealants

In the single study reporting it, caries incidence was 0% in both the laser-alone and acid-etching groups (ungraded, single study).

1 finding from 1 review

Laser enamel preparation alone (Er,Cr:YSGG or CO2 laser) vs Acid-etching (phosphoric acid)

Acceptability · Caries-free children to young adults with premolars/molars requiring pit-and-fissure sealants

Both laser and acid-etching preparation were well accepted by patients (VAS, P = 1.000; ungraded, single study).

1 finding from 1 review

Laser enamel preparation alone (Er,Cr:YSGG or CO2 laser) vs Acid-etching (phosphoric acid)

Clinical (chair-side) time · Caries-free children to young adults with premolars/molars requiring pit-and-fissure sealants

Laser conditioning was reported to take less chair-side time than acid-etching in the studies that measured it, but times were not pooled (ungraded, narrative).

1 finding from 1 review

Laser enamel preparation alone (Er,Cr:YSGG or CO2 laser) vs Acid-etching (phosphoric acid)

Sealant retention rate (completely retained) · Caries-free children to young adults with premolars/molars requiring pit-and-fissure sealants

At 18 months, laser preparation alone did not differ significantly from acid-etching for sealant retention (OR 0.82, 95% CI 0.23 to 2.85; ungraded, single study, high risk of bias).

6 findings from 1 review
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CPP-ACP enamel pre-treatment for prevention of white spot lesions before bonding metallic orthodontic brackets vs No enamel pre-treatment before bonding, or treatment with another material

Shear bond strength (SBS) of metallic orthodontic brackets · Extracted permanent human teeth (enamel); sound or demineralized

CPP-ACP enamel pre-treatment before bonding did not significantly affect the shear bond strength of metallic orthodontic brackets (MD 1.163 MPa, 95% CI -0.321 to 2.648; ungraded).

1 finding from 1 review

CPP-ACP enamel pre-treatment for prevention of white spot lesions before bonding metallic orthodontic brackets vs No enamel pre-treatment before bonding, or treatment with another material

Shear bond strength (SBS) of metallic orthodontic brackets · Sound enamel of extracted permanent human teeth

When used to prevent white spot lesions on sound enamel, CPP-ACP pre-treatment did not significantly affect shear bond strength (MD 1.009, 95% CI -0.723 to 2.740; ungraded).

1 finding from 1 review

CPP-ACP enamel pre-treatment for remineralization of white spot lesions before bonding metallic orthodontic brackets vs No enamel pre-treatment before bonding, or treatment with another material

Shear bond strength (SBS) of metallic orthodontic brackets · Demineralized enamel of extracted permanent human teeth

When used to remineralize white spot lesions on demineralized enamel, CPP-ACP pre-treatment did not significantly affect shear bond strength (MD 1.501, 95% CI -0.630 to 3.632; ungraded).

1 finding from 1 review

Health service and/or policy intervention designed to modify access to oral health information or services for pregnant women, new mothers or other primary caregivers vs Standard care (or any comparator)

Outcome not reported · For interventions, pregnant women, mothers or other caregivers of infants in the first year of life; for outcomes, children up to 6 years…

The review found no eligible studies for this question.

1 finding from 1 review

Package of oral health education/promotion including oral hygiene advice for pregnant women, mothers, infants and young children, plus dietary and feeding practice advice for infants and young children vs usual care

Dental caries · For interventions, pregnant women, mothers or other caregivers of infants in the first year of life; for outcomes, children up to 6 years…

Package of oral health education/promotion including oral hygiene… showed no clear difference in dmfs index score compared with standard care (low certainty).

2 findings from 1 review