Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

1,679 questions · 1,720 findings · 335 reviews · Headline outcomes only

No studies found 192 · 11.2%GRADE not reported 75 · 4.4%Very low 526 · 30.6%Low 504 · 29.3%Moderate 305 · 17.7%High 118 · 6.9%

PERPHENAZINE vs LOW‐POTENCY ANTIPSYCHOTIC DRUGS

Acceptability of treatment ‐ leaving the study early · patients with schizophrenia

It is very uncertain whether comparison 1: PERPHENAZINE changes acceptability of treatment ‐ leaving the study early due to any reason compared with LOW‐POTENCY ANTIPSYCHOTIC DRUGS (very low certainty).

1 finding from 1 review

TRIFLUOPERAZINE vs LOW‐POTENCY ANTIPSYCHOTIC DRUGS

Acceptability of treatment ‐ leaving the study early · patients with schizophrenia

Trifluoperazine showed no clear difference in leaving the study early: 1. Acceptability of treatment ‐ leaving… compared with low‐potency antipsychotic drugs (low certainty).

1 finding from 1 review

Horticultural therapy plus standard care vs usual care

Satisfaction with treatment: leaving the study early Endpoint data (events) · patients with schizophrenia

It is very uncertain whether horticultural therapy plus standard care changes satisfaction with treatment Leaving the study early compared with standard care alone (very low certainty).

1 finding from 1 review

INFORMATION AND COMMUNICATION TECHNOLOGY (ICT) FOR PROMPTING/SUPPORT + STANDARD CARE vs usual care

Acceptability (of intervention): Leaving the studies early – any reason Loss to · patients with treatment compliance for people with serious mental illness

INFORMATION AND COMMUNICATION TECHNOLOGY (ICT) FOR PROMPTING/SUPPORT… showed no clear difference in acceptability (of intervention): Leaving the studies early – any… compared with STANDARD CARE (low certainty).

1 finding from 1 review

TRIFLUOPERAZINE vs placebo

Leaving the study early · patients with schizophrenia

It is very uncertain whether TRIFLUOPERAZINE changes leaving the study early ‐ any reason ‐ medium term Number of… compared with PLACEBO (very low certainty).

1 finding from 1 review

An extended NVP regimen administered to infants for 6 weeks vs sdNVP

Genotypic Resistance to NVP among Indian infants HIV‐infected in utero or through peripartum/early‐breastfeeding transmission Standard Population Sequencing · Breastfeeding infants of HIV‐infected mothers

An extended NVP regimen administered to infants for 6 weeks may leads to higher genotypic Resistance to NVP among Indian infants HIV‐infected in… compared with sdNVP (low certainty).

1 finding from 1 review

STANDARD LOWER DOSE (> 3 to 7.5 mg/day) vs OTHER DOSES

Leaving the study early (2‐10 weeks) vs. standard higher dose (> 7.5‐15 mg/day) · people with the acute phase of schizophrenia

It is very uncertain whether STANDARD LOWER DOSE (> 3 to 7.5 mg/day) changes leaving the study early (2‐10 weeks) vs. standard higher dose (>… compared with OTHER DOSES (very low certainty).

1 finding from 1 review

HALOPERIDOL vs placebo

Leaving the study early · patients with schizophrenia

HALOPERIDOL showed no clear difference in leaving the study early compared with PLACEBO (moderate certainty).

1 finding from 1 review