Cochrane · systematic review · CD009369
Perphenazine versus low‐potency first‐generation antipsychotic drugs for schizophrenia
Tardy, M, Huhn, M, Engel, RR, et al. · Cochrane Database of Systematic Reviews · 2014 · Cochrane Library
SchizophreniaAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
7
current version
GRADE rated
5
No studies
0
Included studies
NR
No studies 0 · 0%Ungraded 2 · 28.6%Very low 1 · 14.3%Low 2 · 28.6%Moderate 2 · 28.6%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Comparison 1: PERPHENAZINE versus LOW‐POTENCY ANTIPSYCHOTIC DRUGS for schizophrenia
Population: patients with schizophrenia
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Response to treatment Comparison 1: PERPHENAZINE vs LOW‐POTENCY ANTIPSYCHOTIC DRUGS | RR 0.97 [0.74, 1.26] | 2 studies · 138 participants | Moderate Downgraded: risk of bias |
Acceptability of treatment ‐ leaving the study early due to any reason Comparison 1: PERPHENAZINE vs LOW‐POTENCY ANTIPSYCHOTIC DRUGS | RR 0.78 [0.35, 1.76] | 3 studies · 323 participants | Very low Downgraded: risk of bias, imprecision, inconsistency |
Adverse effects ‐ at least one adverse effect Comparison 1: PERPHENAZINE vs LOW‐POTENCY ANTIPSYCHOTIC DRUGS | RR 0.83 [0.36, 1.95] | 2 studies · 165 participants | Low Downgraded: risk of bias, imprecision |
Adverse effects ‐ movement disorders ‐ at least one movement disorder Comparison 1: PERPHENAZINE vs LOW‐POTENCY ANTIPSYCHOTIC DRUGS | RR 15.62 [0.94, 260.49] | 1 study · 69 participants | Low Downgraded: risk of bias, imprecision |
Death Comparison 1: PERPHENAZINE vs LOW‐POTENCY ANTIPSYCHOTIC DRUGS | RR 0.14 [0.01, 2.69] | 1 study · 96 participants | Moderate Downgraded: imprecision |
Adverse effects ‐ other ‐ sedation Comparison 1: PERPHENAZINE vs LOW‐POTENCY ANTIPSYCHOTIC DRUGS | no estimate extracted | 0 studies · 0 participants | Ungraded |
Quality of life Comparison 1: PERPHENAZINE vs LOW‐POTENCY ANTIPSYCHOTIC DRUGS | no estimate extracted | 0 studies · 0 participants | Ungraded |