Cochrane · systematic review · CD009268
Haloperidol versus low‐potency first‐generation antipsychotic drugs for schizophrenia
Tardy, M, Huhn, M, Kissling, W, et al. · Cochrane Database of Systematic Reviews · 2014 · Cochrane Library
SchizophreniaAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
7
current version
GRADE rated
5
No studies
0
Included studies
NR
No studies 0 · 0%Ungraded 2 · 28.6%Very low 1 · 14.3%Low 3 · 42.9%Moderate 1 · 14.3%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
HALOPERIDOL versus LOW‐POTENCY ANTIPSYCHOTIC DRUGS for schizophrenia
Population: patients with schizophrenia
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Clinical response to treatment HALOPERIDOL vs LOW‐POTENCY ANTIPSYCHOTIC DRUGS | RR 1.11 [0.86, 1.44] | 14 studies · 574 participants | Low Downgraded: risk of bias, imprecision |
Leaving the study early ‐ Due to any reason HALOPERIDOL vs LOW‐POTENCY ANTIPSYCHOTIC DRUGS | RR 0.82 [0.38, 1.77] | 11 studies · 408 participants | Low Downgraded: risk of bias, imprecision |
Adverse effects ‐ at least one adverse effect HALOPERIDOL vs LOW‐POTENCY ANTIPSYCHOTIC DRUGS | RR 1.97 [0.69, 5.66] | 5 studies · 158 participants | Very low Downgraded: risk of bias, imprecision, inconsistency |
Adverse effects ‐ movement disorders ‐ At least one movement disorder HALOPERIDOL vs LOW‐POTENCY ANTIPSYCHOTIC DRUGS | RR 1.64 [1.22, 2.21] | 5 studies · 170 participants | Low Downgraded: risk of bias, imprecision |
Adverse effects ‐ other ‐ Sedation HALOPERIDOL vs LOW‐POTENCY ANTIPSYCHOTIC DRUGS | RR 0.3 [0.11, 0.82] | 2 studies · 44 participants | Moderate Downgraded: risk of bias |
Death HALOPERIDOL vs LOW‐POTENCY ANTIPSYCHOTIC DRUGS | no estimate extracted | 0 studies · 0 participants | Ungraded |
Quality of life HALOPERIDOL vs LOW‐POTENCY ANTIPSYCHOTIC DRUGS | no estimate extracted | 0 studies · 0 participants | Ungraded |