Cochrane · systematic review · CD010976
Antibiotic regimens for management of intra‐amniotic infection
Chapman, E, Reveiz, L, Illanes, E, et al. · Cochrane Database of Systematic Reviews · 2014 · Cochrane Library
Pregnancy and ChildbirthAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
41
current version
GRADE rated
19
No studies
0
Included studies
NR
No studies 0 · 0%Ungraded 22 · 53.7%Very low 12 · 29.3%Low 6 · 14.6%Moderate 1 · 2.4%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Antibiotics versus antibiotics in labor for management of intra‐amniotic infection
Population: women in labor with management of intra‐amniotic infection
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Maternal death Antibiotics vs antibiotics | no estimate extracted | 1 study · 38 participants | Ungraded |
Neonatal deaths Antibiotics vs antibiotics | RR 1.39 [0.24, 8.06] | 1 study · 133 participants | Very low Downgraded: imprecision |
Neonatal sepsis Antibiotics vs antibiotics | RR 1.07 [0.4, 2.86] | 2 studies · 163 participants | Low Downgraded: imprecision |
Respiratory distress syndrome Antibiotics vs antibiotics | RR 1.69 [0.42, 6.78] | 1 study · 125 participants | Low Downgraded: imprecision |
Maternal postpartum hospital stay (days) Antibiotics vs antibiotics | no estimate extracted | 1 study · 125 participants | Low Downgraded: imprecision |
Postpartum readmission for endometritis Antibiotics vs antibiotics | no estimate extracted | 0 studies · 0 participants | Ungraded |
Treatment failure (endometritis) Antibiotics vs antibiotics | RR 0.86 [0.27, 2.7] | 2 studies · 163 participants | Low Downgraded: imprecision |
Antibiotics versus no treatment during postpartum period for management of intra‐amniotic infection
Population: women with management of intra‐amniotic infection
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Neonatal death Antibiotics vs no treatment during postpartum period | RR 3.32 [0.14, 79.88] | 1 study · 116 participants | Very low Downgraded: imprecision |
Neonatal sepsis Antibiotics vs no treatment during postpartum period | RR 1.11 [0.23, 5.27] | 1 study · 55 participants | Very low Downgraded: imprecision |
Postpartum endometritis Antibiotics vs no treatment during postpartum period | RR 1.48 [0.68, 3.24] | 1 study · 116 participants | Very low Downgraded: imprecision |
Duration of maternal and neonatal hospital stay Antibiotics vs no treatment during postpartum period | no estimate extracted | 0 studies · 0 participants | Ungraded |
Need for additional antibiotic therapy Antibiotics vs no treatment during postpartum period | no estimate extracted | 0 studies · 0 participants | Ungraded |
Postpartum readmission for endometritis Antibiotics vs no treatment during postpartum period | no estimate extracted | 0 studies · 0 participants | Ungraded |
Failure of treatment Antibiotics vs no treatment during postpartum period | no estimate extracted | 0 studies · 0 participants | Ungraded |
Antibiotics versus placebo during postpartum period for management of intra‐amniotic infection
Population: women with management of intra‐amniotic infection
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Maternal and neonatal mortality Antibiotics vs placebo during postpartum period | no estimate extracted | 0 studies · 0 participants | Ungraded |
Maternal and neonatal severe infection Antibiotics vs placebo during postpartum period | no estimate extracted | 0 studies · 0 participants | Ungraded |
Duration of maternal and neonatal hospital stay Antibiotics vs placebo during postpartum period | no estimate extracted | 0 studies · 0 participants | Ungraded |
Endomyometritis Antibiotics vs placebo during postpartum period | no estimate extracted | 2 studies · 288 participants | Ungraded |
Need for additional antibiotic therapy Antibiotics vs placebo during postpartum period | no estimate extracted | 0 studies · 0 participants | Ungraded |
Postpartum readmission for endometritis Antibiotics vs placebo during postpartum period | no estimate extracted | 0 studies · 0 participants | Ungraded |
Treatment failure Antibiotics vs placebo during postpartum period | RR 0.97 [0.14, 6.77] | 2 studies · 288 participants | Very low Downgraded: imprecision |
Antibiotic versus antibiotics during postpartum period for management of intra‐amniotic infection
Population: women with management of intra‐amniotic infection
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Maternal and neonatal mortality Antibiotic vs antibiotics during postpartum period | no estimate extracted | 0 studies · 0 participants | Ungraded |
Maternal and neonatal severe infection Antibiotic vs antibiotics during postpartum period | no estimate extracted | 0 studies · 0 participants | Ungraded |
Length of treatment (days) Antibiotic vs antibiotics during postpartum period | no estimate extracted | 1 study · 131 participants | Very low Downgraded: imprecision |
Endometritis Antibiotic vs antibiotics during postpartum period | no estimate extracted | 0 studies · 0 participants | Ungraded |
Postpartum readmission for endometritis Antibiotic vs antibiotics during postpartum period | no estimate extracted | 0 studies · 0 participants | Ungraded |
Treatment failure Antibiotic vs antibiotics during postpartum period | RR 1.02 [0.27, 3.89] | 1 study · 131 participants | Very low Downgraded: imprecision |
Antibiotics (short duration) compared with antibiotics (long duration) postpartum for management of intra‐amniotic infection
Population: women with management of intra‐amniotic infection
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Maternal and neonatal mortality Antibiotics (short duration) vs antibiotics (long duration) postpartum | no estimate extracted | 0 studies · 0 participants | Ungraded |
Wound infection Antibiotics (short duration) vs antibiotics (long duration) postpartum | RR 1.87 [0.17, 20.37] | 1 study · 292 participants | Low Downgraded: imprecision |
Duration of hospital stay (days) Antibiotics (short duration) vs antibiotics (long duration) postpartum | no estimate extracted | 1 study · 292 participants | Moderate Downgraded: imprecision |
Need for additional antibiotic therapy Antibiotics (short duration) vs antibiotics (long duration) postpartum | no estimate extracted | 0 studies · 0 participants | Ungraded |
Endometritis Antibiotics (short duration) vs antibiotics (long duration) postpartum | no estimate extracted | 0 studies · 0 participants | Ungraded |
Postpartum readmission for endometritis Antibiotics (short duration) vs antibiotics (long duration) postpartum | no estimate extracted | 0 studies · 0 participants | Ungraded |
Treatment failure (vaginal and cesarean delivery) Antibiotics (short duration) vs antibiotics (long duration) postpartum | RR 1.31 [0.42, 4.02] | 1 study · 292 participants | Low Downgraded: imprecision |
Intrapartum compared with postpartum treatment
Population: women with management of intra‐amniotic infection
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Maternal and neonatal mortality Intrapartum vs postpartum treatment | no estimate extracted | 0 studies · 0 participants | Ungraded |
Maternal bacteremia Intrapartum vs postpartum treatment | RR 2.19 [0.25, 19.48] | 1 study · 45 participants | Very low Downgraded: imprecision |
Early neonatal sepsis Intrapartum vs postpartum treatment | RR 0.08 [0, 1.44] | 1 study · 45 participants | Very low Downgraded: imprecision |
Neonatal pneumonia or sepsis Intrapartum vs postpartum treatment | RR 0.06 [0, 0.95] | 1 study · 45 participants | Very low Downgraded: imprecision |
Maternal postpartum hospital stay (days) Intrapartum vs postpartum treatment | no estimate extracted | 1 study · 45 participants | Very low Downgraded: imprecision |
Neonatal hospital stay Intrapartum vs postpartum treatment | no estimate extracted | 1 study · 45 participants | Very low Downgraded: imprecision |
Endometritis/Failure treatment Intrapartum vs postpartum treatment | no estimate extracted | 0 studies · 0 participants | Ungraded |