Cochrane · systematic review · CD009396
Trifluoperazine versus low‐potency first‐generation antipsychotic drugs for schizophrenia
Tardy, M, Dold, M, Engel, RR, et al. · Cochrane Database of Systematic Reviews · 2014 · Cochrane Library
SchizophreniaAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
7
current version
GRADE rated
4
No studies
0
Included studies
NR
No studies 0 · 0%Ungraded 3 · 42.9%Very low 0 · 0%Low 3 · 42.9%Moderate 1 · 14.3%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Trifluoperazine versus low‐potency antipsychotic drugs for schizophrenia
Population: patients with schizophrenia
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Response to treatment ‐ medium term Trifluoperazine vs low‐potency antipsychotic drugs | RR 0.96 [0.59, 1.56] | 3 studies · 120 participants | Low Downgraded: risk of bias, imprecision |
Leaving the study early: 1. Acceptability of treatment ‐ leaving early due to any reason Trifluoperazine vs low‐potency antipsychotic drugs | RR 1.25 [0.72, 2.17] | 3 studies · 239 participants | Low Downgraded: risk of bias, imprecision |
Adverse events: 1. General ‐ at least one adverse effect Trifluoperazine vs low‐potency antipsychotic drugs | RR 1.6 [0.94, 2.74] | 1 study · 60 participants | Moderate Downgraded: risk of bias |
Adverse events: 2.a. Specific ‐ movement disorders ‐ at least one movement disorder Trifluoperazine vs low‐potency antipsychotic drugs | RR 2.08 [0.78, 5.55] | 2 studies · 123 participants | Low Downgraded: risk of bias, imprecision |
Death Trifluoperazine vs low‐potency antipsychotic drugs | no estimate extracted | 0 studies · 4 participants | Ungraded |
Sedation Trifluoperazine vs low‐potency antipsychotic drugs | no estimate extracted | 0 studies · 5 participants | Ungraded |
Quality of life Trifluoperazine vs low‐potency antipsychotic drugs | no estimate extracted | 0 studies · 5 participants | Ungraded |