Side effects or other adverse events · Orthodontic patients (any age) undergoing orthodontic treatment (mostly fixed appliances)
No adverse effects were reported in any of the seven included studies (ungraded).
1 finding from 1 review
Immediate (24 h) resin-dentin bond strength (MPa) · Artificial caries-affected dentin (ACAD) in extracted permanent human teeth (in vitro)
In the Self-Etch adhesive + chemical ACAD protocol network, Silica vs HEMA showed no significant difference in 24 h bond strength (MD -1.059, 95% CI -9.024 to 6.906; Moderate certainty).
1 finding from 1 review
Intervention not reported
Early childhood caries (ECC), prevalence
1 finding from 1 review
Prevalence 59 [52, 67]
9 studies
GRADE not reported
Immediate (24 h) resin-dentin bond strength (MPa) · Artificial caries-affected dentin (ACAD) in extracted permanent human teeth (in vitro)
In the Self-Etch adhesive + chemical ACAD protocol network, Calcium vs Control showed no significant difference in 24 h bond strength (MD -1.124, 95% CI -5.917 to 3.670; Moderate certainty).
1 finding from 1 review
Intervention not reported
Amalgam: Preference for replacement over repair - Scenario 2: loss of dental hard substance adjacent to the restoration
The intervention led to higher amalgam: Preference for replacement over repair - Scenario 2: loss…; GRADE not reported.
1 finding from 1 review
RR 4.81 [3.14, 7.37]
11 studies
GRADE not reported
Salivary Streptococcus mutans count and plaque index · Adults with dental caries
No meta-analysis was conducted; postbiotic lozenges were reported to reduce salivary Streptococcus mutans counts and plaque index versus placebo.
1 finding from 1 review
no estimate extracted
1 study
GRADE not reported
Immediate (24 h) resin-dentin bond strength (MPa) · Artificial caries-affected dentin (ACAD) in extracted permanent human teeth (in vitro)
In the Self-Etch adhesive + chemical ACAD protocol network, Flavonoids vs Silica showed no significant difference in 24 h bond strength (MD 3.764, 95% CI -5.241 to 12.769; Moderate certainty).
1 finding from 1 review
Amalgam: Preference for replacement over repair - Scenario 7: non-stable (mobile) restoration · Dentists managing a defective direct amalgam restoration (posterior occlusal Class I; standardized vignette of a 30-year-old,…
For a defective amalgam restoration with non-stable (mobile) restoration, surveyed dentists most often preferred replacement over repair (pooled RR 24.22; p < 0.001); ungraded.
1 finding from 1 review
Early childhood caries (ECC) · Children aged 0-5 years in North Africa
Having one sibling was associated with higher odds of ECC (OR 3.32).
1 finding from 1 review
OR 3.32 [1.15, 9.54]
1 study
GRADE not reported
Composite: Preference for replacement over repair - Scenario 7: non-stable (mobile) restoration · Dentists managing a defective direct resin composite restoration (posterior occlusal Class I; standardized vignette of a 30-year-old,…
For a defective composite restoration with non-stable (mobile) restoration, surveyed dentists most often preferred replacement over repair (pooled RR 12.17; p < 0.001); ungraded.
1 finding from 1 review
Treatment success (caries lesion arrest or restoration survival) · Children (aged 3-11 y) with cavitated caries lesions in primary teeth
At 6 months, the Hall technique had significantly higher treatment success than partial caries removal (OR 13.49; moderate certainty).
1 finding from 1 review
OR 13.49 [1.83, 99.68]
44 studies
Moderate
Intervention not reported
Composite: Preference for replacement over repair - Scenario 6: superficial discoloration
The intervention led to lower composite: Preference for replacement over repair - Scenario 6:…; GRADE not reported.
1 finding from 1 review
RR 0.20 [0.14, 0.29]
6 studies
GRADE not reported
Caries experience · Patients with anorexia nervosa aged >=12 years (mean age ~18.4; entirely female in reported data), general community-dwelling population
Anorexia nervosa is associated with significantly higher caries experience (DMFT) than healthy controls (MD 2.00 teeth, 95% CI 0.87 to 3.13; low certainty).
1 finding from 1 review
Intervention not reported
Composite: Preference for replacement over repair - Scenario 1: partial loss or fracture of the restoration
The intervention showed no clear difference in composite: Preference for replacement over repair - Scenario 1:…; GRADE not reported.
1 finding from 1 review
RR 0.73 [0.52, 1.03]
Studies not reported
GRADE not reported
Adequate periodontal tissue · Children receiving dental restorations (aged 4-11 years; primary teeth; Class I/II/V cavities)
Uncertain whether IRR and CR differ in periodontal tissue outcomes (low certainty; downgraded for very serious inconsistency).
1 finding from 1 review
Pain as a factor of choice · (Potential) patients with freedom of choice regarding dental treatments, including parents and caregivers deciding for children or…
Pain was the fourth most frequently reported factor (N=49 articles), reported across most countries (ungraded).
1 finding from 1 review
'Pain' (synonyms e.g., 'pain intensity') identified in N=49 articles (code frequency n=61); frequent in Brazil (43%), Canada (25%) and the USA (23%), not identified in Germany (0); reported across about 34 countries…
49 studies
GRADE not reported
Radiographic proximal caries lesion progression · Children and adults with non-cavitated proximal (interproximal) caries lesions in primary and/or permanent teeth (ages 3-45)
Microinvasive techniques probably reduce radiographic progression of non-cavitated proximal caries lesions compared with non-invasive measures (moderate certainty).
1 finding from 1 review
Cell death / cytotoxicity · Streptococcus mutans (in vitro cultures and biofilms)
One study reported minimal cytotoxicity (<1% cell damage) with grape seed extract (ungraded).
1 finding from 1 review
Dental caries · Children aged 2 to 8 years
The review reported a lower odds ratio at maternal prenatal vitamin D ≤50 nmol/L than at ≤35 nmol/L, without a numeric value in the available sources.
1 finding from 1 review
Enamel surface microhardness · Human enamel specimens around orthodontic brackets (in vitro)
In vitro, a nano-hydroxyapatite-containing orthodontic composite showed significant enamel remineralization versus control in a single study (ungraded).
1 finding from 1 review