Question · asked by 1 review
Grape seed extract (GSE) and its proanthocyanidin fractions vs Untreated or vehicle control (some studies vs positive antimicrobial controls, e.g. chlorhexidine/fluoride): Cell death / cytotoxicity
- Population
- Streptococcus mutans (in vitro cultures and biofilms)
- Intervention
- Grape seed extract (GSE) and its proanthocyanidin fractions
- Comparison
- Untreated or vehicle control (some studies vs positive antimicrobial controls, e.g. chlorhexidine/fluoride)
- Outcome
- Cell death / cytotoxicity
One study reported minimal cytotoxicity (<1% cell damage) with grape seed extract (ungraded).
What each review found
Include earlier review versions| Finding | Effect | Studies | GRADE certainty |
|---|---|---|---|
Grape seed extract (GSE) and its proanthocyanidin fractions vs Untreated or vehicle control (some studies vs positive antimicrobial controls, e.g. chlorhexidine/fluoride) Cell death / cytotoxicity · Streptococcus mutans (in vitro cultures and biofilms) · in vitro (laboratory) One study reported minimal cytotoxicity (<1% cell damage) with grape seed extract (ungraded). Effect of flavonoids from grape seed and cranberry extracts on the microbiological activity of Streptococcus… (2024) All outcomes | GSE showed a very low level of cell damage (<1%, few visible dead cells) (Furiga). | 1 study | GRADE not reported |
Findings are shown side by side, never pooled across reviews.
The reviews
| Review | Searched up to | Included studies | AMSTAR 2 |
|---|---|---|---|
| Effect of flavonoids from grape seed and cranberry extracts on the microbiological activity of Streptococcus mutans: a systematic review… 2024 All outcomes | 2023-12-30 | 22 | Critically Low / Critically Low |
How reviews are matched to this question
Reviews word the same question differently. Four decision models (TypeSafe's Jev, Liquid AI's d1-ultra, SubQ Snap and Baseten's Elephant) judged each wording of the population, intervention, comparator and outcome against the others; two wordings count as the same when at least three of them agree and none clearly disagrees, and findings count as this question only when all four elements match. Timing, setting and subgroup never split a question: they are shown on each finding.