Question · asked by 1 review
Fluoride mouthrinse (0.05-0.32% sodium fluoride or amine fluoride) added to daily fluoride toothpaste vs Control: fluoride toothpaste alone, placebo mouthrinse + toothpaste, or non-fluoride (chlorhexidine) mouthrinse + toothpaste: Side effects or other adverse events
- Population
- Orthodontic patients (any age) undergoing orthodontic treatment (mostly fixed appliances)
- Intervention
- Fluoride mouthrinse (0.05-0.32% sodium fluoride or amine fluoride) added to daily fluoride toothpaste
- Comparison
- Control: fluoride toothpaste alone, placebo mouthrinse + toothpaste, or non-fluoride (chlorhexidine) mouthrinse + toothpaste
- Outcome
- Side effects or other adverse events
No adverse effects were reported in any of the seven included studies (ungraded).
What each review found
Include earlier review versions| Finding | Effect | Studies | GRADE certainty |
|---|---|---|---|
Fluoride mouthrinse (0.05-0.32% sodium fluoride or amine fluoride) added to daily fluoride toothpaste vs Control: fluoride toothpaste alone, placebo mouthrinse + toothpaste, or non-fluoride (chlorhexidine) mouthrinse + toothpaste Adverse effects / harms (side effects) · Children, adolescents and adults undergoing fixed (multi-bracket) orthodontic treatment · During treatment, Clinical orthodontic (fixed multi-bracket appliance) treatment No adverse effects were reported in any of the seven included studies (ungraded). Fluoride mouthrinses for prevention of initial caries in orthodontic patients - a systematic review and… (2025) All outcomes | No side- or adverse effects were reported in any of the included reports. | 7 studies · 704 participants | GRADE not reported |
Findings are shown side by side, never pooled across reviews.
The reviews
| Review | Searched up to | Included studies | AMSTAR 2 |
|---|---|---|---|
| Fluoride mouthrinses for prevention of initial caries in orthodontic patients - a systematic review and meta-analysis. 2025 All outcomes | September 30, 2024 | 9 | Low / Critically Low |
How reviews are matched to this question
Reviews word the same question differently. Four decision models (TypeSafe's Jev, Liquid AI's d1-ultra, SubQ Snap and Baseten's Elephant) judged each wording of the population, intervention, comparator and outcome against the others; two wordings count as the same when at least three of them agree and none clearly disagrees, and findings count as this question only when all four elements match. Timing, setting and subgroup never split a question: they are shown on each finding.