Search review questions

White spot lesion formation measured by QLF · Patients undergoing fixed orthodontic treatment · Before and after treatment

Dental caries · Children (<18 years) with vs without dental caries · Over-dominant model (TT+GG vs TG)

Antioxidant capacity · Streptococcus mutans (in vitro cultures and biofilms)

Caries arrestment at the surface level · Children and adults with active dental caries (aged 1-50; mostly preschool/school children with primary dentition) · 12 to 18 months, Overall (all comparators pooled)

Dental caries risk · Institutionalized orphan children · Overall (pooled)

dmfs index score · For interventions, pregnant women and mothers of infants in the first year of life; for outcomes, children up to 6…

Overall success (composite of clinical and radiographic success) · Permanent teeth with carious pulp exposure · >=12 months, Unspecified/mixed diagnosis

Caries arrest · Children and adults (with or without carious lesions) · Permanent dentition (root)

Dental caries prevalence (any dmft), dichotomous · Brazilian children under 5 years in primary dentition (BMI classified by WHO 2006 Z-score)

Early childhood caries (ECC) · Children aged <6 years · Time period: After 2018

Dental caries (prevalence) · Adults · Female

Dental caries - SNP-based heritability · Japanese adults (present-study cohort) · Lifelong (germline genotype), LDSC heritability (present study)

Overall success (composite of clinical and radiographic success) · Permanent teeth with carious pulp exposure · >=12 months, Partial pulpotomy

Overall success (composite of clinical and radiographic success) · Full pulpotomy, unspecified/mixed diagnosis

Dental caries · Children aged 2 to 8 years · Maternal pregnancy to child age 2 to 8 years, Meta-regression adjusted for gestational age, child age, and maternal vitamin D level

Caries arrestment at the tooth level · Children and adults without systemic diseases affecting dental health · 6 months to 12 months

Dental caries · Children (<18 years) with vs without dental caries · Recessive model (CC vs CT+TT)

Dental caries prevalence (any dmft), dichotomous · Brazilian children in primary dentition (BMI classified by CDC 2000 growth charts)

Caries arrest · Children and adults (with or without carious lesions) · Permanent dentition (coronal)

Caries arrest · Children and adults (with or without carious lesions) · 18 months, Primary dentition (coronal)

Spontaneous space closure · Children and adolescents after extraction of a mandibular permanent first molar (before eruption of the second molar) · Until eruption of the permanent second molar (median follow-up 4.0 years), Mandible

GtfB/C and F-ATPase activity · Streptococcus mutans (in vitro cultures and biofilms)

Early childhood caries experience (mean dmft) · Children younger than 71 months (under 6 years) · Region: Central/South America

Adverse effects · Children and adults (with or without carious lesions) · 12 to 30 months, Adults

Early childhood caries experience (mean dmft) · Children younger than 71 months (under 6 years) · Overall (all regions)

Dental caries · Children (<18 years) with vs without dental caries · Over-dominant model (CC+AA vs CA)

Overall success (composite of clinical and radiographic success) · Permanent teeth with carious pulp exposure · >=12 months

Serum 25-hydroxyvitamin D level · Preschool children ≤6 years, North America · North America

Spontaneous space closure · Children and adolescents after extraction of a mandibular permanent first molar (before eruption of the second molar) · Until eruption of the permanent second molar (median follow-up 4.0 years), Mandible

Oral disease prevalence · Adult residents of slum and non-slum urban settings in LMICs

Bacterial growth inhibition · Streptococcus mutans cultures and biofilms

Dental caries in children · Children (approx. 4-18 years)

Early childhood caries (ECC) · Children aged ≤6 years (early childhood) · Exposure and outcome assessed concurrently (observational); children aged ≤6 years, Time period: 2018 and later

Dental caries · Children (<18 years) with vs without dental caries · Recessive model (GG vs GA+AA)

Enamel demineralization / white spot lesions (DIAGNOdent, QLF) · Patients undergoing fixed orthodontic (fixed appliance) treatment (adolescents and adults, ages 12 to 35) · 1 to 6 months (to debonding)

Dental pain or sensitivity · Children and adults (with or without carious lesions)

Adverse effects (tooth staining; soft-tissue and systemic events) · Children and adults with active dental caries (aged 1-50; mostly preschool/school children with primary dentition) · up to 30 months

Dental caries · Children (<18 years) with vs without dental caries · Over-dominant model (TT+CC vs TC), PCR-RFLP genotyping

Dental caries · Children (<18 years) with vs without dental caries · Recessive model (TT vs TC+CC), Caucasian ethnicity

Negative predictive value · Children and adults with primary or permanent dentition undergoing dental caries assessment · Cross-sectional diagnostic accuracy (index test vs reference standard, in-vivo), Overall (studies reporting NPV; narrative synthesis)

Decayed surfaces (DS) · Periodontal disease severity (CDC-AAP); single study (Robert 2019); adjusted

Early childhood caries experience (mean dmft) · Children younger than 71 months (under 6 years) · GNI $20000-$39999

Adverse effects · Children and adults (with or without carious lesions) · 24 hours to 30 months, Children

Early childhood caries (ECC) prevalence (%, dmft>0) · Children younger than 71 months (under 6 years) · GNI $10000-$19999

Early childhood caries (ECC) prevalence (%, dmft>0) · Children younger than 71 months (under 6 years) · Gini index: low inequality

Untreated dental caries (d component), continuous · Brazilian children/adolescents (BMI classified by WHO 2007 Z-score)

Early childhood caries (ECC) · Preschool children ≤6 years

Overall success (composite of clinical and radiographic success) · Permanent teeth with carious pulp exposure · >=12 months

Self-perceived (self-rated) oral health status · Adult residents of slums and non-slum urban settings of LMICs · Cross-sectional, By age, sex, socioeconomic class, employment

Dental caries / early childhood caries (ECC) · Children (approx. 4-18 years) · Study design: cohort