Search review questions

Gtf activity · Streptococcus mutans (in vitro cultures and biofilms)

Overjet · Children and adolescents (aged 16 years or younger) with prominent lower front teeth (Class III malocclusion) · 6-year follow-up

Overjet · Children and adolescents (aged 16 years or younger) with prominent lower front teeth (Class III malocclusion) · End of treatment

White spot lesions / enamel demineralization (photographic scoring, DIAGNOdent, micro-CT) · Patients undergoing fixed orthodontic (fixed appliance) treatment (adolescents and adults, ages 12 to 35) · 8 weeks to full treatment (to debonding)

Calcium and phosphate ion release · Human enamel specimens around orthodontic brackets (in vitro) · up to 42 days, Overall

Oral cancer (OC) · Adults in case-control studies of oral cancer · Not specified, Missing teeth (per tooth)

Dental caries prevalence in children · Meta-regression adjusted estimate

Self-esteem (Oral Aesthetic Subjective Impact Score, OASIS) · Children and adolescents (aged 16 years or younger) with prominent lower front teeth (Class III malocclusion) · 6-year follow-up

Difficulty in speech (participant-reported proxy) · People of any age with a confirmed diagnosis, by clinical examination and biopsy, of oral submucous fibrosis (OSF)

Fluorosis (percentage prevalence in permanent teeth) · Children exposed to topical fluoride when under 6 years old; fluorosis assessed in permanent teeth at 6 to 18 years · Fluorosis assessed when most permanent teeth of interest had erupted (6 to 18 years)

Dental caries in children · Children of mothers assessed for smoking status during pregnancy (early childhood dental caries) · Exposure during pregnancy; caries assessed in early childhood, Sample size: >3000

Salivary S. mutans level · Humans with salivary bacteria measured · Overall

Early childhood caries (ECC) · Children aged ≤6 years (early childhood) · Exposure and outcome assessed concurrently (observational); children aged ≤6 years, Sample collection: oral swab

Change in prevalence of salivary Streptococcus sobrinus · Single study (Stsepetova et al. 2019), erythritol and xylitol vs sorbitol, not pooled

Antioxidant capacity · Streptococcus mutans (in vitro cultures and biofilms)

Dental caries (early childhood caries) · Preschool children (<6 years) · Cohort studies

Dental caries prevalence and severity · Persons with disabilities (children and adults with autism, Down syndrome, cerebral palsy, hearing impairment, or… · Cross-sectional

Burning sensation (VAS 0-100) · People of any age with a confirmed diagnosis, by clinical examination and biopsy, of oral submucous fibrosis (OSF)

Self-esteem (Piers-Harris self-concept scale) · Children and adolescents (aged 16 years or younger) with prominent lower front teeth (Class III malocclusion) · End of treatment

Bracket failure · Patients undergoing fixed orthodontic treatment · During orthodontic treatment

Primary caries prevention · Children and adults (with or without carious lesions) · 36 months, Permanent dentition (root)

Dental caries in children · Infants and children (aged about 2 to 8 years) whose mothers' vitamin D status was assessed during pregnancy · Maternal 25(OH)D measured at gestational weeks 24 to 38, Gestational-age subgroup: weeks 24 to 38

Early childhood caries (ECC) · Children aged ≤6 years (early childhood) · Exposure and outcome assessed concurrently (observational); children aged ≤6 years, Study design: case-control

Overall success (composite of clinical and radiographic success) · Permanent teeth with carious pulp exposure · >=12 months, Mature teeth

Mixed-type caries (crown and root) · Adults · Mixed-type caries

Wits appraisal · Children and adolescents (aged 16 years or younger) with prominent lower front teeth (Class III malocclusion) · End of treatment

Maximal mouth opening (interincisal distance) · People of any age with a confirmed diagnosis, by clinical examination and biopsy, of oral submucous fibrosis (OSF)

Caries arrestment at the individual (patient) level · Children and adults with active dental caries (aged 1-50; mostly preschool/school children with primary dentition) · 3 weeks to 12 months, SDF vs NSF

Caries arrest · Children and adults (with or without carious lesions) · 24 to 36 months, Primary dentition

Postoperative discomfort or pain · People of any age with a confirmed diagnosis, by clinical examination and biopsy, of oral submucous fibrosis (OSF)

Serum vitamin D (25(OH)D): ECC vs caries-free · Region: North America (Fig 4)

Early childhood caries (ECC) prevalence (%, dmft>0) · Children younger than 71 months (under 6 years) · GNI >$40000

Maximal mouth opening (interincisal distance) · People of any age with a confirmed diagnosis, by clinical examination and biopsy, of oral submucous fibrosis (OSF) · Less than 3 months

Dental caries · Children (<18 years) with vs without dental caries · Dominant model (AA+AG vs GG)

Burning sensation (VAS 0-100) · People of any age with a confirmed diagnosis, by clinical examination and biopsy, of oral submucous fibrosis (OSF) · 3 to 6 months

Rotation of the mandibular second premolar · Children and adolescents after extraction of a mandibular permanent first molar (before eruption of the second molar) · Until eruption of the permanent second molar (median follow-up 4.0 years), Mandible

Early childhood caries (ECC) · Children aged <6 years · Time period: 2017 and before

Difficulty in swallowing (participant-reported proxy) · People of any age with a confirmed diagnosis, by clinical examination and biopsy, of oral submucous fibrosis (OSF)

Primary caries prevention · Children and adults (with or without carious lesions) · 36 months, Primary dentition

Overall success (composite of clinical and radiographic success) · Full pulpotomy, mature teeth

Secondary prevention of caries · Children and adults (with or without carious lesions) · Permanent dentition (root)

Adverse events for mother or child · For interventions, pregnant women, mothers or other caregivers of infants in the first year of life; for outcomes,…

Enamel remineralization extent · Human enamel specimens around orthodontic brackets (in vitro) · pH cycling 30 days, Overall

Dental caries / early childhood caries (ECC) · Children (approx. 4-18 years)

Dental caries in children · Children (approx. 4-18 years) · Continuous BMI, direct pooling (studies reporting BMI as a continuous variable)

Dental caries / early childhood caries (ECC) · Children (approx. 4-18 years) · Study design: case-control

Time to next/working arch wire · People receiving orthodontic treatment with fixed appliances (upper and/or lower full arch)

Enamel surface microhardness · Human tooth enamel specimens, sound/intact (in vitro) · After cariogenic acid challenge / pH cycling, sound enamel

Dental caries · Children (<18 years) with vs without dental caries · Dominant model (CC+CA vs AA)

Fluorosis (percentage prevalence in permanent teeth) · Children exposed to topical fluoride when under 6 years old; fluorosis assessed in permanent teeth at 6 to 18 years · Fluorosis assessed when most permanent teeth of interest had erupted (6 to 18 years)