Search review questions

Spontaneous space closure · Children and adolescents after extraction of a mandibular permanent first molar (before eruption of the second molar) · Until eruption of the permanent second molar (median follow-up 4.0 years), Mandible

Dental caries prevalence (any DMFT), dichotomous · Brazilian children/adolescents in permanent dentition (BMI classified by WHO 2006 Z-score)

dmft index score · For interventions, pregnant and lactating women; for outcomes, children up to 6 years of age · Children assessed at 5-6 yrs

Overall success (composite of clinical and radiographic success) · Permanent teeth with carious pulp exposure · >=12 months

Spontaneous space closure · Children and adolescents after extraction of a mandibular permanent first molar (before eruption of the second molar) · Until eruption of the permanent second molar (median follow-up 4.0 years), Mandible

Early childhood caries (ECC) prevalence (%, dmft>0) · Children younger than 71 months (under 6 years) · Region: Asia-Oceania

Early childhood caries experience (mean dmft) · Children younger than 71 months (under 6 years) · GNI $5000-$9999

Pattern of dental service utilisation and barriers · Adult residents of slums and non-slum urban settings of LMICs

Overall success (composite of clinical and radiographic success) · Permanent teeth with carious pulp exposure · >=12 months, Hemostasis >=10 min

Child plaque (any plaque visible on any teeth) · For interventions, pregnant women, mothers or other caregivers of infants in the first year of life; for outcomes,…

White spot lesion incidence · Patients undergoing fixed orthodontic treatment · 2 and 4 months after treatment start

Primary caries prevention · Children and adults (with or without carious lesions)

Primary caries prevention · Children and adults (with or without carious lesions) · 36 months, Permanent dentition (root)

Periodontal disease - SNP-based heritability · Japanese adults (present-study cohort) · Lifelong (germline genotype), LDSC heritability (present study)

Biofilm morphological changes · Streptococcus mutans (in vitro cultures and biofilms)

Dental caries in children · Children (approx. 4-18 years) · Non-linear dose-response (restricted cubic splines)

Dental caries · Children (<18 years) with vs without dental caries · Recessive model (GG vs GA+AA), Zhang 2006 removed, Sensitivity analysis (Zhang 2006 excluded)

Mother gingival health (mild or moderate bone loss) · For interventions, pregnant women, mothers or other caregivers of infants in the first year of life; for outcomes,…

Frequency of mouth cleaning · Adult residents of slums and non-slum urban settings of LMICs · Cross-sectional, Slum/disadvantaged vs non-slum/urban

White spot lesion rate and volume · Patients undergoing fixed orthodontic treatment · 8 weeks after bonding

Caries severity (d1 + mfs >= 5) · For interventions, pregnant women, mothers or other caregivers of infants in the first year of life; for outcomes,… · Children assessed at 4 yrs

Salivary IL-8 level (pg/mL) · Children and young adults (3-25 years)

Enamel demineralization / white spot lesion prevention (DIAGNOdent, enamel mineral content) · Patients undergoing fixed orthodontic (fixed appliance) treatment (adolescents and adults, ages 12 to 35) · 1 day to 6 months

Fluorosis (percentage prevalence in permanent teeth) · Children exposed to topical fluoride when under 6 years old; fluorosis assessed in permanent teeth at 6 to 18 years · Fluorosis assessed when most permanent teeth of interest had erupted (6 to 18 years)

Oral cancer risk · People with and without more than 15 missing teeth · Missing teeth >15

Secondary prevention of caries · Children and adults (with or without carious lesions)

Enamel demineralization / white spot lesions (DIAGNOdent, photographic scoring) · Patients undergoing fixed orthodontic (fixed appliance) treatment (adolescents and adults, ages 12 to 35) · 1, 3 and 6 months (during treatment to debonding)

Decayed surfaces (DS) · Percentage of sites with CAL >=3 mm (tertiles); single study (Robert 2019); adjusted

Permanent-teeth caries experience (DMF/DMFT, mean score) · Institutionalized orphan children (roughly 3 to 18 years) · Overall (pooled)

Child oral health behaviour · For interventions, pregnant women, mothers or other caregivers of infants in the first year of life; for outcomes,…

Dental caries · Children (<18 years) with vs without dental caries · Over-dominant model (AA+GG vs GA), Zhang 2006 removed, Sensitivity analysis (Zhang 2006 excluded)

Dental caries prevalence (any DMFT), dichotomous · Brazilian children/adolescents in permanent dentition (BMI classified by CDC 2000 growth charts)

Overall success (composite of clinical and radiographic success) · Permanent teeth with carious pulp exposure · >=12 months, Irreversible pulpitis

Early childhood caries experience (mean dmft) · Children younger than 71 months (under 6 years) · Gini index: no inequalities

Dental caries (ECC) · Preschool children under 6 years of age · First dental examination before age 6 years, Cohort studies; sensitivity analysis excluding studies 48 and 52

Oral cancer (OC) · Adults in case-control studies of oral cancer · Not specified, Overall (all missing-teeth measures pooled)

Dental caries in children · Children of mothers assessed for smoking status during pregnancy (early childhood dental caries) · Exposure during pregnancy; caries assessed in early childhood, Children's age: >3 years

Oral disease burden, slum vs non-slum urban comparison · Adult residents of slums and non-slum urban settings of LMICs · Cross-sectional, Slum vs non-slum urban / general population

Dental caries - genome-wide-significant loci · Japanese adults (present-study cohort: 30,859 dental caries cases / 14,666 controls) · Lifelong (germline genotype), Present-study GWAS (Japanese)

Spontaneous space closure · Children and adolescents after extraction of a mandibular permanent first molar (before eruption of the second molar) · Until eruption of the permanent second molar (median follow-up 4.0 years), Mandible

Dental caries (early childhood caries) · Preschool children (<6 years) · Cohort studies

Caries arrestment at the tooth level · Children and adults with active dental caries (aged 1-50; mostly preschool/school children with primary dentition) · 6 to 12 months, Overall (all comparators pooled)

Dental caries (early childhood caries) · Preschool children (<6 years) · Cohort studies

Cariogenic microbiota counts (Streptococcus mutans, Lactobacillus spp.) · Narrative synthesis: significantly higher in CLP vs controls (Ahluwalia, Lucas, Hassani, Cheng, Sundell)

Overall success (composite of clinical and radiographic success) · Immature teeth, normal pulp/reversible pulpitis

Dental pain or sensitivity · Children and adults (with or without carious lesions) · 12 months, Children

Photographic white spot lesion score · Patients undergoing fixed orthodontic treatment · Before and after treatment

Early childhood caries (ECC) prevalence (%, dmft>0) · Children younger than 71 months (under 6 years) · Overall (all regions)

Secondary prevention of caries · Children and adults (with or without carious lesions)

Early childhood caries (ECC) · Children with average age ≤3 years · Average age: ≤3 years