Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

1,888 questions · 2,009 findings · 352 reviews

No studies found 224 · 11.1%GRADE not reported 265 · 13.2%Very low 551 · 27.4%Low 540 · 26.9%Moderate 311 · 15.5%High 118 · 5.9%

Early treatment (two-phase: phase 1 in childhood, phase 2 in adolescence) with functional appliance vs Late treatment (one-phase in adolescence) with functional appliance

Incidence of incisal trauma · Children (7 to 11 years) and adolescents (12 to 16 years) with prominent upper front teeth (Class II malocclusion)

Early treatment (two-phase: phase 1 in childhood, phase 2 in… showed no clear difference in incidence of incisal trauma compared with late treatment (one-phase in adolescence) with functional appliance; GRADE not reported.

1 finding from 1 review

Early treatment (two-phase: phase 1 in childhood, phase 2 in adolescence) with functional appliance vs Late treatment (one-phase in adolescence) with functional appliance

PAR score · Children (7 to 11 years) and adolescents (12 to 16 years) with prominent upper front teeth (Class II malocclusion)

Early treatment (two-phase: phase 1 in childhood, phase 2 in… led to lower PAR score compared with late treatment (one-phase in adolescence) with functional appliance; GRADE not reported.

2 findings from 1 review

Zuclopenthixol dihydrochloride vs placebo

Leaving the study early · patients with schizophrenia

It is very uncertain whether zuclopenthixol dihydrochloride changes leaving the study early (any reason) compared with placebo (very low certainty).

2 findings from 2 reviews · compare the 2 reviews

Summary of findings table ‐ Cognitive behavioural therapy plus standard care vs control

Leaving the study early ‐ for any reason ‐ overall acceptability (combined time points) · recent‐onset psychosis (less than three years since the start of psychotic symptoms and either first or second psychotic episode)

Summary of findings table ‐ Cognitive behavioural therapy plus… showed no clear difference in leaving the study early ‐ for any reason ‐ overall acceptability… compared with control (moderate certainty).

1 finding from 1 review

Summary of findings table ‐ CBT without antipsychotics vs CBT plus antipsychotics

Leaving the study early/ loss to · schizophrenia

It is very uncertain whether summary of findings table ‐ CBT without antipsychotics changes leaving the study early ‐ for any reason ‐ overall acceptability… compared with CBT plus antipsychotics (very low certainty).

1 finding from 1 review

Summary of findings table ‐ CBT without antipsychotics vs no specific treatment

Leaving the study early/ loss to · schizophrenia

Summary of findings table ‐ CBT without antipsychotics showed no clear difference in leaving the study early ‐ for any reason ‐ overall acceptability… compared with no specific treatment (low certainty).

1 finding from 1 review

Summary of findings table ‐ CBT without antipsychotics vs antipsychotics

Leaving the study early/ loss to · schizophrenia

It is very uncertain whether summary of findings table ‐ CBT without antipsychotics changes leaving the study early ‐ for any reason ‐ overall acceptability… compared with antipsychotics (very low certainty).

1 finding from 1 review

Percutaneous vs open surgical PD catheter insertion

Early PD catheter function (within 4 weeks of PD catheter insertion) · improving catheter function and clinical outcomes in PD patients

It is very uncertain whether percutaneous changes early PD catheter function (within 4 weeks of PD catheter insertion) compared with open surgical PD catheter insertion (very low certainty).

1 finding from 1 review

Peritoneoscopic vs open surgical PD catheter insertion

Early PD catheter function (within 4 weeks of PD catheter insertion) · improving catheter function and clinical outcomes in PD patients

It is very uncertain whether peritoneoscopic changes early PD catheter function (within 4 weeks of PD catheter insertion)… compared with open surgical PD catheter insertion (very low certainty).

1 finding from 1 review

Medical vs open surgical PD catheter insertion

Early PD catheter function (within 4 weeks of PD catheter insertion) · improving catheter function and clinical outcomes in PD patients

Medical showed no clear difference in early PD catheter function (within 4 weeks of PD catheter insertion) compared with open surgical PD catheter insertion (low certainty).

1 finding from 1 review

Magnetic seizure therapy plus standard care vs electroconvulsive therapy plus standard care

Dropout · people with the acute phase of schizophrenia

It is very uncertain whether magnetic seizure therapy plus standard care changes leaving the study early: any reasonassessed by: number of dropouts… compared with electroconvulsive therapy plus standard care (very low certainty).

1 finding from 1 review