Cochrane · systematic review · CD010598
Zuclopenthixol versus placebo for schizophrenia
Lacey, M, Jayaram, MB · Cochrane Database of Systematic Reviews · 2015 · Cochrane Library
SchizophreniaAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
21
current version
GRADE rated
3
No studies
18
Included studies
NR
No studies 18 · 85.7%Ungraded 0 · 0%Very low 3 · 14.3%Low 0 · 0%Moderate 0 · 0%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
ZUCLOPENTHIXOL DIHYDROCHLORIDE versus PLACEBO for schizophrenia
Population: people with with schizophrenia
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Clinically significant response on global state ‐ as defined by each of the studies, Improvement (CGI) ‐ short term ‐ as rated by nurse Improvement (CGI) ‐ short term ‐ as rated by psychiatrist ZUCLOPENTHIXOL DIHYDROCHLORIDE vs PLACEBO | RR 2.57 [1.06, 6.2] | 1 study · 29 participants | Very low Downgraded: risk of bias, imprecision |
Relapse as defined by the studies ZUCLOPENTHIXOL DIHYDROCHLORIDE vs PLACEBO | no estimate extracted | NR | No studies |
Clinically significant response on psychotic symptoms ‐ as defined by each of the studies. ZUCLOPENTHIXOL DIHYDROCHLORIDE vs PLACEBO | no estimate extracted | NR | No studies |
Adverse effects: Sedation ZUCLOPENTHIXOL DIHYDROCHLORIDE vs PLACEBO | RR 4.67 [1.23, 17.68] | 1 study · 29 participants | Very low Downgraded: risk of bias, imprecision |
Leaving the study early ZUCLOPENTHIXOL DIHYDROCHLORIDE vs PLACEBO | RR 0.93 [0.06, 13.54] | 1 study · 29 participants | Very low Downgraded: risk of bias, imprecision |
Average change in quality of life/satisfaction ZUCLOPENTHIXOL DIHYDROCHLORIDE vs PLACEBO | no estimate extracted | NR | No studies |
Significant change in quality of life/satisfaction ‐ as defined by each of the studies ZUCLOPENTHIXOL DIHYDROCHLORIDE vs PLACEBO | no estimate extracted | NR | No studies |
ZUCLOPENTHIXOL ACETATE versus PLACEBO for schizophrenia
Population: people with schizophrenia
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Clinically significant response on global state ZUCLOPENTHIXOL ACETATE vs PLACEBO | no estimate extracted | NR | No studies |
Relapse as defined by the studies ZUCLOPENTHIXOL ACETATE vs PLACEBO | no estimate extracted | NR | No studies |
Clinically significant response on psychotic symptoms ‐ as defined by each of the studies. ZUCLOPENTHIXOL ACETATE vs PLACEBO | no estimate extracted | NR | No studies |
Other adverse effects, general and specific ZUCLOPENTHIXOL ACETATE vs PLACEBO | no estimate extracted | NR | No studies |
Leaving the study early ZUCLOPENTHIXOL ACETATE vs PLACEBO | no estimate extracted | NR | No studies |
Average change in quality of life/satisfaction ZUCLOPENTHIXOL ACETATE vs PLACEBO | no estimate extracted | NR | No studies |
Significant change in quality of life/satisfaction ‐ as defined by each of the studies ZUCLOPENTHIXOL ACETATE vs PLACEBO | no estimate extracted | NR | No studies |
ZUCLOPENTHIXOL DECANOATE versus PLACEBO for schizophrenia
Population: people with schizophrenia
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Clinically significant response on global state ZUCLOPENTHIXOL DECANOATE vs PLACEBO | no estimate extracted | NR | No studies |
Relapse as defined by the studies ZUCLOPENTHIXOL DECANOATE vs PLACEBO | no estimate extracted | NR | No studies |
Clinically significant response on psychotic symptoms ‐ as defined by each of the studies ZUCLOPENTHIXOL DECANOATE vs PLACEBO | no estimate extracted | NR | No studies |
Other adverse effects, general and specific ZUCLOPENTHIXOL DECANOATE vs PLACEBO | no estimate extracted | NR | No studies |
Leaving the study early ZUCLOPENTHIXOL DECANOATE vs PLACEBO | no estimate extracted | NR | No studies |
Average change in quality of life/satisfaction ZUCLOPENTHIXOL DECANOATE vs PLACEBO | no estimate extracted | NR | No studies |
Significant change in quality of life/satisfaction ‐ as defined by each of the studies ZUCLOPENTHIXOL DECANOATE vs PLACEBO | no estimate extracted | NR | No studies |