Cochrane · systematic review · CD015331
Cognitive behavioural therapy added to standard care for first‐episode and recent‐onset psychosis
Mayer, SF, Corcoran, C, Kennedy, L, et al. · Cochrane Database of Systematic Reviews · 2024 · Cochrane Library
SchizophreniaAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
5
current version
GRADE rated
5
No studies
0
Included studies
NR
No studies 0 · 0%Ungraded 0 · 0%Very low 1 · 20%Low 2 · 40%Moderate 2 · 40%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Summary of findings table ‐ Cognitive behavioural therapy plus standard care compared to control for first‐episode or recent‐onset psychosis
Population: first‐episode or recent‐onset psychosis
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Mental state ‐ general: mean endpoint overall symptom scales (high = poor) (combined time points) Summary of findings table ‐ Cognitive behavioural therapy plus standard care vs control | no estimate extracted | 20 studies · 1508 participants | Low Downgraded: risk of bias, inconsistency |
Global state ‐ number of participants with relapse/exacerbations of psychosis (combined time points) Summary of findings table ‐ Cognitive behavioural therapy plus standard care vs control | RR 0.82 [0.57, 1.18] | 7 studies · 693 participants | Low Downgraded: imprecision |
Leaving the study early ‐ for any reason ‐ overall acceptability (combined time points) Summary of findings table ‐ Cognitive behavioural therapy plus standard care vs control | RR 0.87 [0.72, 1.05] | 25 studies · 2242 participants | Moderate Downgraded: imprecision |
Functioning ‐ mean endpoint functioning scale (high = good) (combined time points) Summary of findings table ‐ Cognitive behavioural therapy plus standard care vs control | no estimate extracted | 18 studies · 1241 participants | Moderate Downgraded: risk of bias |
Adverse events ‐ participants with at least one adverse event ‐ < 12 months Summary of findings table ‐ Cognitive behavioural therapy plus standard care vs control | RR 1.29 [0.85, 1.97] | 1 study · 43 participants | Very low Downgraded: imprecision |