Cochrane · systematic review · CD013326
Hand hygiene for the prevention of infections in neonates
Kuti, BP, Ogunlesi, TA, Oduwole, O, et al. · Cochrane Database of Systematic Reviews · 2023 · Cochrane Library
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
10
current version
GRADE rated
6
No studies
4
Included studies
NR
No studies 4 · 40%Ungraded 0 · 0%Very low 5 · 50%Low 0 · 0%Moderate 1 · 10%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Show all 2 versionsTwo per cent CHG compared to alcohol hand sanitiser (61% alcohol and emollients) for the prevention of infections in neonates
Population: Neonates and caregivers
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Incidence of (author‐defined) suspected infections within the first 28 days of life Two per cent CHG vs alcohol hand sanitiser (61% alcohol and emollients) | no estimate extracted | NR | No studies |
Incidence of bacteriologically confirmed infections (types of infection as specified by authors) within the first 28 days of life Two per cent CHG vs alcohol hand sanitiser (61% alcohol and emollients) | RR 0.79 [0.66, 0.93] | 1 study · 2932 participants | Moderate Downgraded: risk of bias |
All‐cause mortality within the first seven days of life (early neonatal death) Two per cent CHG vs alcohol hand sanitiser (61% alcohol and emollients) | no estimate extracted | NR | No studies |
All‐cause mortality from the 8th to 28th day of life (late neonatal death) Two per cent CHG vs alcohol hand sanitiser (61% alcohol and emollients) | no estimate extracted | NR | No studies |
Alcohol‐based handrub compared to usual care for the prevention of infections in neonates
Population: Neonates and caregivers
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Incidence of suspected infections (author‐defined) within the first 28 days of life Alcohol‐based handrub vs usual care | RR 0.98 [0.69, 1.39] | 1 study · 103 participants | Very low Downgraded: imprecision, indirectness |
Incidence of bacteriologically confirmed infections within the first 28 days of life Alcohol‐based handrub vs usual care | no estimate extracted | NR | No studies |
All‐cause mortality within the first seven days of life (early neonatal death) Alcohol‐based handrub vs usual care | RR 0.29 [0.01, 7] | 1 study · 103 participants | Very low Downgraded: imprecision, indirectness |
All‐cause mortality from the 8th to 28th day of life (late neonatal death) Alcohol‐based handrub vs usual care | RR 0.29 [0.01, 7] | 1 study · 103 participants | Very low Downgraded: imprecision, indirectness |
Four per cent chlorhexidine + hand hygiene promotion compared to usual care for prevention of infections in neonates
Population: Neonates and caregivers
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Authors reported adverse outcomes (events without hospitalisation) Four per cent chlorhexidine + hand hygiene promotion vs usual care | RR 0.57 [0.28, 1.15] | 1 study · 246 participants | Very low Downgraded: risk of bias |
Adverse events requiring hospitalisation (SAE) Four per cent chlorhexidine + hand hygiene promotion vs usual care | RR 1.83 [0.75, 4.42] | 1 study · 246 participants | Very low Downgraded: risk of bias |