Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

214 questions · 217 findings · 40 reviews · Pain, Palliative and Supportive Care

No studies found 35 · 16.1%GRADE not reported 2 · 0.9%Very low 49 · 22.6%Low 43 · 19.8%Moderate 48 · 22.1%High 40 · 18.4%

Intervention not reported

At least 30% reduction in pain or equivalent (moderate) · adults with fibromyalgia
1 finding from 1 review

Tramadol vs pethidine

Proportion of participants with moderate to severe pain up to 6 hours after the procedure · children undergoing surgery

Tramadol showed no clear difference in number of patients with moderate to severe pain (PACU) compared with pethidine (low certainty).

1 finding from 1 review

Tramadol vs fentanyl

Proportion of participants with moderate to severe pain up to 6 hours after the procedure · children undergoing surgery

The review found no eligible studies for this question.

1 finding from 1 review

Tramadol vs morphine

Proportion of participants with moderate to severe pain up to 6 hours after the procedure · children undergoing surgery

The review found no eligible studies for this question.

1 finding from 1 review

Intervention not reported

At least 30% reduction in pain or equivalent (moderate) · adults with fibromyalgia

The review found no eligible studies for this question.

1 finding from 1 review

Intervention not reported

"Moderate" benefit At least 30% reduction in pain · adults with neuropathic pain (Trigeminal neuralgia, painful diabetic neuropathy, chronic post stroke pain)
1 finding from 1 review

Intervention not reported

"Moderate" benefit At least 30% reduction in pain · Adults with cancer pain

The review found no eligible studies for this question.

1 finding from 1 review

Nalbuphine vs placebo

Number of patients with moderate/severe pain (1 hour postoperatively) · children undergoing surgery

Nalbuphine may leads to lower number of patients with moderate/severe pain (1 hour postoperatively) compared with placebo (low certainty).

2 findings from 1 review

Nalbuphine vs morphine

Number of patients with moderate/severe pain (1 hour postoperatively) · children undergoing surgery

Nalbuphine showed no clear difference in number of patients with moderate/severe pain (1 hour postoperatively) compared with morphine (low certainty).

2 findings from 1 review

Intervention not reported

"Moderate" benefit At least 30% reduction in pain · neuropathic pain (5 studies in painful diabetic neuropathy and polyneuropathy)

The review found no eligible studies for this question.

1 finding from 1 review

Intervention not reported

Patient Global Impression of Change much or very much improved (patient global evaluation of pain relief complete, good or moderate) · neuropathic pain (6 studies in central neuropathic pain due to multiple sclerosis, spinal cord injury, polyneuropathy, central post‐stroke…
1 finding from 1 review

Intervention not reported

"Moderate" benefit At least 30% reduction in pain · adults with peripheral neuropathic pain conditions
1 finding from 1 review

Intervention not reported

Patient Global Impression of Change much or very much improved (PGPR "complete", "a lot", or "moderate") · adults with neuropathic pain (3 studies in painful diabetic neuropathy and postherpetic neuralgia)
1 finding from 1 review

Summary of findings: complete control of vomiting during the overall phase (MEC) when vs treatment with granisetron

Interventions (corticosteroids included in all regimens)a · adult cancer patients at risk for CINV caused by moderately emetogenic chemotherapy

The review found no eligible studies for this question.

1 finding from 1 review