Search review questions

Composite: Preference for replacement over repair - Scenario 5: open margin · Coverage: Not covering

Veillonella dispar relative abundance · Children under 6 years with severe early childhood caries and caries-free controls

Immediate (24 h) resin-dentin bond strength (MPa) · Artificial caries-affected dentin (ACAD) in extracted permanent human teeth (in vitro) · 24 h (immediate), Self-Etch + chemical ACAD

Immediate (24 h) resin-dentin bond strength (MPa) · permanent human teeth with artificial caries-affected dentin · 24 h, Etch-and-Rinse; chemical ACAD

Early childhood caries (ECC) - incidence/risk · Sensitivity analysis (Feldens 2010 excluded): breastfeeding >12 months

Specificity · Imaging modality: Bitewing radiographs

Immediate (24 h) resin-dentin bond strength (MPa) · Artificial caries-affected dentin (ACAD) in extracted permanent human teeth (in vitro) · 24 h (immediate), Etch-and-Rinse + chemical ACAD

Adverse effects / harms (side effects) · Children, adolescents and adults undergoing fixed (multi-bracket) orthodontic treatment · During treatment

Immediate (24 h) resin-dentin bond strength (MPa) · Artificial caries-affected dentin (ACAD) in extracted permanent human teeth (in vitro) · 24 h (immediate), Self-Etch + chemical ACAD

Oral health-related quality of life (OHRQoL sum score, transformed 0-100) · Community-dwelling elderly persons aged ≥60 years · Severe inequality

Early childhood caries (ECC), prevalence · Study site: urban

Forearm fracture · European GWAS participants · SVMR MR-Egger

Immediate (24 h) resin-dentin bond strength (MPa) · Artificial caries-affected dentin (ACAD) in extracted permanent human teeth (in vitro) · 24 h (immediate), Self-Etch + chemical ACAD

Early childhood caries (ECC) · Children aged 0-5 years in North Africa · 60-71 months

Caries prevalence (early childhood caries) · Preschool children aged <=71 months (caries outcome assessed at 3-6 years) · Caries prevalence at 4-6 years, Overall

Amalgam: Preference for replacement over repair - Scenario 2: loss of dental hard substance adjacent to the restoration · Continent: Asia

Salivary Streptococcus mutans count and plaque index · Adults with dental caries · 4 weeks

Immediate (24 h) resin-dentin bond strength (MPa) · Artificial caries-affected dentin (ACAD) in extracted permanent human teeth (in vitro) · 24 h (immediate), Self-Etch + chemical ACAD

Amalgam: Preference for replacement over repair - Scenario 7: non-stable (mobile) restoration · Dentists managing a defective direct amalgam restoration (posterior occlusal Class I; standardized vignette of a… · Not applicable (single time-point survey, June to October 2023), Overall (all 21 countries pooled)

Early childhood caries (ECC) · Children aged 0-5 years in North Africa · 1 sibling

Composite: Preference for replacement over repair - Scenario 7: non-stable (mobile) restoration · Dentists managing a defective direct resin composite restoration (posterior occlusal Class I; standardized vignette of… · Not applicable (single time-point survey, June to October 2023), Overall (all 21 countries pooled)

Hip/femoral bone mineral density (BMD) · Females (all ages) · Long-term / lifetime fluoride exposure, Females, low-to-moderate risk-of-bias studies: 4.0 mg/L vs null

Treatment success (caries lesion arrest or restoration survival) · Children (aged 3-11 y) with cavitated caries lesions in primary teeth · 6 months, 6-month follow-up

Composite: Preference for replacement over repair - Scenario 6: superficial discoloration · Continent: Europe

Caries experience (DMFT index) · Patients with anorexia nervosa aged >=12 years (mean age ~18.4; entirely female in reported data), general…

Dental caries (study-defined binary; assessed by DMFT, number of dental caries, or dentist diagnosis) · Adults (≥18 years) · By sample size: n < 5000

Forearm fracture · European GWAS participants · SVMR Maximum Likelihood

Immediate (24 h) resin-dentin bond strength (MPa) · Artificial caries-affected dentin (ACAD) in extracted permanent human teeth (in vitro) · 24 h (immediate), Etch-and-Rinse + chemical ACAD

Composite: Preference for replacement over repair - Scenario 1: partial loss or fracture of the restoration · Coverage: Not covering

Negative oral-health impact on daily performance (OIDP or Child-OIDP) · Adolescents aged 10 to 19 years · Cross-sectional (concurrent exposure and outcome); oral impacts recalled over the prior 6 months, Caries-definition subgroup: presence of dental caries

Dental caries (presence/absence) · Children and adolescents under 18 years with HIV · Not specified (cross-sectional), Cross-sectional studies

Occlusal caries detection: specificity · Patients (in vivo); permanent and primary teeth, occlusal surfaces · Overall (all dentition)

Caries experience (mean DMFT) · 12-year-old children across European countries (national/regional epidemiological surveys, 2011-2022) · Cross-sectional (survey data 2011-2022), High unemployment (>10%)

Adequate periodontal tissue · Children receiving dental restorations (aged 4-11 years; primary teeth; Class I/II/V cavities) · 1.5 to 2 years

Pain as a factor of choice · (Potential) patients with freedom of choice regarding dental treatments, including parents and caregivers deciding for…

Radiographic progression of proximal caries lesions · Children and adults with non-cavitated proximal (interproximal) caries lesions in primary and/or permanent teeth (ages… · Final follow-up (1 to 7 years across trials), Overall (all microinvasive vs non-invasive pooled)

Spine bone mineral density · Females · Females, low-to-moderate risk-of-bias studies: 0.7 to 2.35 mg/L vs null

Cell death / cytotoxicity · Streptococcus mutans (in vitro cultures and biofilms)

Dental caries · Children aged 2 to 8 years · Maternal pregnancy to child age 2 to 8 years, Vitamin D threshold ≤50 nmol/L

Superficial surface (enamel) mineralization (surface microhardness) · Human enamel specimens around orthodontic brackets (in vitro) · pH cycling 28 days, Overall

Caries presence in primary teeth · For interventions, pregnant women, mothers or other caregivers of infants in the first year of life; for outcomes,… · Children assessed at 1-6 yrs

Dental caries (self-reported history) · Japanese adults (present-study direct-to-consumer genetic testing cohort); self-reported disease cases vs controls · Lifelong (germline genotype), MAGMA gene-based test (present study)

pH change or lactic acid production · Streptococcus mutans cultures and biofilms

Pocket closure · Adults (> 18 years) with a clinical diagnosis of periodontitis, receiving active (non-surgical anti-infective) treatment · 3 months (change from baseline)

Dental caries · Primary school children in Ethiopia

Caries arrestment at the individual (patient) level · Children and adults with active dental caries (aged 1-50; mostly preschool/school children with primary dentition) · 3 weeks to 12 months, Overall (all comparators pooled)

Ever utilised dental services · Adult residents of slums and non-slum urban settings of LMICs · Lifetime (ever), Slum vs non-slum; urban vs rural; by sex

Change in Mutans streptococci (MS) and Lactobacilli in saliva · Schoolchildren (6-9 years), high caries risk · 42 days, Single study (Cocco 2019); not pooled

Overall oral health-related quality of life (OHRQoL) impact (self- and proxy/caregiver-reported) · Persons with disabilities (children and adults with autism, Down syndrome, cerebral palsy, hearing impairment, or… · Cross-sectional

Hospital admission (length of stay) · People of any age with a confirmed diagnosis, by clinical examination and biopsy, of oral submucous fibrosis (OSF)