Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

15 questions · 15 findings · 13 reviews · Pain, Palliative and Supportive Care

No studies found 1 · 6.7%GRADE not reported 0 · 0%Very low 9 · 60%Low 2 · 13.3%Moderate 2 · 13.3%High 1 · 6.7%

Oxycodone MR vs placebo

Withdrawals due to adverse events · adults with neuropathic pain (2 studies in peripheral diabetic neuropathy and 1 study in postherpetic neuralgia)
1 finding from 1 review

Mirtazapine vs placebo

Withdrawals due to adverse events · adults with fibromyalgia

Mirtazapine showed no clear difference in tolerability: withdrawals due to adverse events compared with placebo (low certainty).

1 finding from 1 review

Topical clonidine (TC) vs placebo

Withdrawals due to adverse events · adults with painful diabetic neuropathy

Topical clonidine (TC) showed no clear difference in withdrawals due to adverse events during longest compared with placebo (low certainty).

1 finding from 1 review