Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

33 questions · 33 findings · 28 reviews · Pain, Palliative and Supportive Care

No studies found 3 · 9.1%GRADE not reported 0 · 0%Very low 21 · 63.6%Low 6 · 18.2%Moderate 3 · 9.1%High 0 · 0%

Naldemedine vs placebo

Serious adverse eventsh · people with cancer irrespective of whether receiving palliative care and with opioid‐induced bowel dysfunction

Naldemedine showed no clear difference in serious adverse eventsh compared with placebo (low certainty).

1 finding from 1 review

Oxycodone MR vs placebo

Serious adverse events · adults with neuropathic pain (2 studies in peripheral diabetic neuropathy and 1 study in postherpetic neuralgia)
1 finding from 1 review