Cochrane · systematic review · CD012294
Ketorolac for postoperative pain in children
McNicol, ED, Rowe, E, Cooper, TE · Cochrane Database of Systematic Reviews · 2018 · Cochrane Library
Pain, Palliative and Supportive CareAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
7
current version
GRADE rated
6
No studies
0
Included studies
NR
No studies 0 · 0%Ungraded 1 · 14.3%Very low 6 · 85.7%Low 0 · 0%Moderate 0 · 0%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Ketorolac versus placebo for postoperative pain in children
Population: children with postoperative pain
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Number of participants with 50% or greater postoperative pain relief Ketorolac vs placebo | no estimate extracted | 0 studies · 0 participants | Ungraded |
Postoperative pain intensity Ketorolac vs placebo | no estimate extracted | 0 studies · 0 participants | Very low Downgraded: risk of bias, imprecision, inconsistency |
Participants using rescue medication in the PACU Ketorolac vs placebo | RR 0.85 [0.71, 1] | 4 studies · 262 participants | Very low Downgraded: risk of bias, imprecision, inconsistency |
Opioid consumption (mg IV morphine equivalents): PACU Ketorolac vs placebo | no estimate extracted | 3 studies · 162 participants | Very low Downgraded: risk of bias, imprecision |
Opioid consumption (mg IV morphine equivalents): 0 to 4 h Ketorolac vs placebo | no estimate extracted | 2 studies · 129 participants | Very low Downgraded: risk of bias, imprecision, inconsistency |
Serious adverse events Ketorolac vs placebo | no estimate extracted | 2 studies · 128 participants | Very low Downgraded: risk of bias, imprecision |
Participants experiencing bleeding events Ketorolac vs placebo | RR 0.99 [0.64, 1.52] | 5 studies · 258 participants | Very low Downgraded: risk of bias |