What do systematic reviews say?

Aromatherapy vs placebo or control

• Aromatherapy for dementia 2020 · Cochrane Headline outcomes only
  no estimate extracted
  2 studies · 134 participants
  Very low

Chemotherapy vs chemotherapy alone

• Salvage systemic therapy for advanced gastric and oesophago‐gastric junction adenocarcinoma 2020 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 70 participants
  Very low

Gene therapy vs no gene therapy control

• Gene therapy for peripheral arterial disease 2018 · Cochrane Headline outcomes only
  no estimate extracted
  6 studies · 699 participants
  Very low

Music therapy vs placebo or usual care

• Music therapy for autistic people 2022 · Cochrane Headline outcomes only
  no estimate extracted
  3 studies · 340 participants
  Moderate

Concomitant (concurrent) chemoradiotherapy vs chemoradiotherapy plus surgery

• Chemoradiotherapy versus chemoradiotherapy plus surgery for esophageal cancer 2017 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 165 participants
  Very low

Laminectomy plus radiotherapy vs radiotherapy

The review found no eligible studies for this question.

• Interventions for the treatment of metastatic extradural spinal cord compression in adults 2015 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Delayed chemotherapy vs immediate chemotherapy

• Survival differences with immediate versus delayed chemotherapy for asymptomatic incurable metastatic colorectal cancer 2018 · Cochrane Headline outcomes only
  no estimate extracted
  2 studies · 161 participants
  Very low

Radiotherapy (morning) vs Afternoon radiotherapy

• Interventions for the treatment of oral cavity and oropharyngeal cancer: radiotherapy 2010 · Cochrane All outcomes
  Bjarnason 2009: no statistically significant difference in quality of life scores (data not reported). Morning radiotherapy was associated with significantly less weight loss after 5 months.
  1 study · 216 participants
  GRADE not reported

Chemotherapy vs no chemotherapy

The review found no eligible studies for this question.

• Management of people with intermediate‐stage hepatocellular carcinoma 2017 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Pre-radiotherapy extraction of healthy molar teeth vs Conservative treatment (leaving the teeth in place during radiotherapy, with oral health education and disease prevention: oral hygiene, fluoride, diet advice)

The review found no eligible studies for this question.

• Dental extractions prior to radiotherapy to the jaws for reducing post‐radiotherapy dental complications 2013 · Cochrane All outcomes
  no estimate extracted
  0 studies
  No studies found

Pre-radiotherapy extraction of diseased molar teeth vs Conservative treatment (restoration of the teeth and leaving them in place during radiotherapy, with oral health education and disease prevention: oral hygiene, fluoride, diet advice)

The review found no eligible studies for this question.

• Dental extractions prior to radiotherapy to the jaws for reducing post‐radiotherapy dental complications 2013 · Cochrane All outcomes
  no estimate extracted
  0 studies
  No studies found

SUPPORTIVE THERAPY vs cognitive behavioural therapy

• Supportive therapy for schizophrenia 2015 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 65 participants
  Very low

High‐pressure garment therapy vs low‐pressure garment therapy

The review found no eligible studies for this question.

• Pressure‐garment therapy for preventing hypertrophic scarring after burn injury 2024 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Hypofractionated radiotherapy vs radiotherapy

The review found no eligible studies for this question.

• Radiotherapy for diffuse brainstem glioma in children and young adults 2016 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Hyperfractionated radiotherapy vs radiotherapy

The review found no eligible studies for this question.

• Radiotherapy for diffuse brainstem glioma in children and young adults 2016 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Platinum‐containing chemotherapy vs chemotherapy without platinum

The review found no eligible studies for this question.

• Platinum‐based chemotherapy for early triple‐negative breast cancer 2023 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

ATRA in addition to chemotherapy vs chemotherapy alone

The review found no eligible studies for this question.

• Effects of all‐trans retinoic acid (ATRA) in addition to chemotherapy for adults with acute myeloid leukaemia (AML)… 2018 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Radiotherapy vs control

• Radiotherapy for neovascular age‐related macular degeneration 2020 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  Low

Laser therapy vs no laser therapy

The review found no eligible studies for this question.

• Laser therapy for retinopathy in sickle cell disease 2022 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Combined HBO and perioperative antibiotics prior to dental implant therapy vs antibiotics alone

• Interventions for preventing osteoradionecrosis of the jaws in adults receiving head and neck radiotherapy 2019 · Cochrane All outcomes

  1 year
  This comparison was only made in 1 study which reported no serious adverse events associated with HBO therapy. Quality of life measures (oral status, functioning, satisfaction) showed emotional functioning and pain…
  1 study · 26 participants
  Very low