Cochrane · systematic review · CD011960
Effects of all‐trans retinoic acid (ATRA) in addition to chemotherapy for adults with acute myeloid leukaemia (AML) (non‐acute promyelocytic leukaemia (non‐APL))
Küley‐Bagheri, Y, Kreuzer, KA, Monsef, I, et al. · Cochrane Database of Systematic Reviews · 2018 · Cochrane Library
HaematologyAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
8
current version
GRADE rated
7
No studies
1
Included studies
NR
No studies 1 · 12.5%Ungraded 0 · 0%Very low 3 · 37.5%Low 0 · 0%Moderate 4 · 50%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
ATRA in addition to chemotherapy compared to chemotherapy only for adults with acute myeloid leukaemia (AML) (non‐acute promyelocytic leukaemia (APL))
Population: adults with acute myeloid leukaemia (AML) (non‐acute promyelocytic leukaemia (APL))
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Mortality (instead of overall survival) ATRA in addition to chemotherapy vs chemotherapy only | HR 0.94 [0.87, 1.02] | 7 studies · 2985 participants | Moderate Downgraded: risk of bias, imprecision, inconsistency |
Quality of life ATRA in addition to chemotherapy vs chemotherapy only | no estimate extracted | NR | No studies |
Mortality, relapse and progresses (instead of disease‐ or relapse‐free survival) ATRA in addition to chemotherapy vs chemotherapy only | HR 0.99 [0.87, 1.12] | 3 studies · 1258 participants | Moderate Downgraded: risk of bias, imprecision, inconsistency |
On‐study mortality ATRA in addition to chemotherapy vs chemotherapy only | RR 1.02 [0.81, 1.3] | 5 studies · 2839 participants | Moderate Downgraded: risk of bias, imprecision, inconsistency |
Infection grade III/IV ATRA in addition to chemotherapy vs chemotherapy only | RR 1.05 [0.96, 1.15] | 3 studies · 1428 participants | Moderate Downgraded: risk of bias, imprecision, inconsistency |
Diarrhoea grade III/IV ATRA in addition to chemotherapy vs chemotherapy only | RR 2.19 [1.07, 4.47] | 2 studies · 337 participants | Very low Downgraded: risk of bias, imprecision, inconsistency |
Nausea/vomiting grade III/IV ATRA in addition to chemotherapy vs chemotherapy only | RR 1.46 [0.75, 2.85] | 2 studies · 337 participants | Very low Downgraded: risk of bias, imprecision, inconsistency |
Cardiac toxicity grade III/IV ATRA in addition to chemotherapy vs chemotherapy only | RR 0.46 [0.24, 0.9] | 3 studies · 1428 participants | Very low Downgraded: risk of bias, imprecision, inconsistency |