Cochrane · systematic review · CD010439
Radiotherapy for diffuse brainstem glioma in children and young adults
Hu, X, Fang, Y, Hui, X, et al. · Cochrane Database of Systematic Reviews · 2016 · Cochrane Library
Childhood CancerAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
14
current version
GRADE rated
7
No studies
7
Included studies
NR
No studies 7 · 50%Ungraded 0 · 0%Very low 2 · 14.3%Low 4 · 28.6%Moderate 1 · 7.1%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Hyperfractionated radiotherapy compared with conventional radiotherapy for diffuse brainstem glioma in children and young adults
Population: children and young adults with diffuse brainstem glioma
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Overall survival Hyperfractionated radiotherapy vs conventional radiotherapy | HR 1.07 [0.75, 1.53] | 1 study · 130 participants | Low Downgraded: risk of bias, imprecision |
Progression‐free survival Hyperfractionated radiotherapy vs conventional radiotherapy | no estimate extracted | NR | No studies |
Event‐free survival Hyperfractionated radiotherapy vs conventional radiotherapy | HR 1.26 [0.83, 1.9] | 1 study · 130 participants | Low Downgraded: risk of bias, imprecision |
Quality of life Hyperfractionated radiotherapy vs conventional radiotherapy | no estimate extracted | NR | No studies |
Neurological response Hyperfractionated radiotherapy vs conventional radiotherapy | no estimate extracted | NR | No studies |
Radiological response defined as the number of participants with a reduction in tumour size > 50% Hyperfractionated radiotherapy vs conventional radiotherapy | RR 0.94 [0.54, 1.63] | 1 study · 108 participants | Very low Downgraded: risk of bias, imprecision |
Toxicities Hyperfractionated radiotherapy vs conventional radiotherapy | no estimate extracted | 1 study · 112 participants | Very low Downgraded: risk of bias, imprecision |
Hypofractionated radiotherapy compared with conventional radiotherapy for diffuse brainstem glioma in children and young adults
Population: children and young adults with diffuse brainstem glioma
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Overall survival Hypofractionated radiotherapy vs conventional radiotherapy | HR 1.03 [0.53, 2.01] | 1 study · 71 participants | Moderate Downgraded: imprecision |
Progression‐free survival Hypofractionated radiotherapy vs conventional radiotherapy | HR 1.19 [0.63, 2.22] | 1 study · 71 participants | Low Downgraded: imprecision |
Event‐free survival Hypofractionated radiotherapy vs conventional radiotherapy | no estimate extracted | NR | No studies |
Quality of life Hypofractionated radiotherapy vs conventional radiotherapy | no estimate extracted | NR | No studies |
Neurological response Hypofractionated radiotherapy vs conventional radiotherapy | no estimate extracted | NR | No studies |
Radiological response Hypofractionated radiotherapy vs conventional radiotherapy | no estimate extracted | NR | No studies |
Toxicities Hypofractionated radiotherapy vs conventional radiotherapy | no estimate extracted | 1 study · 71 participants | Low Downgraded: imprecision |