Cochrane · systematic review · CD010511
Chemoradiotherapy versus chemoradiotherapy plus surgery for esophageal cancer
Vellayappan, BA, Soon, YY, Ku, GY, et al. · Cochrane Database of Systematic Reviews · 2017 · Cochrane Library
GutAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
5
current version
GRADE rated
5
No studies
0
Included studies
NR
No studies 0 · 0%Ungraded 0 · 0%Very low 1 · 20%Low 2 · 40%Moderate 1 · 20%High 1 · 20%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Chemoradiotherapy versus chemoradiotherapy plus surgery for esophageal cancer
Population: nonmetastatic esophageal cancer
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Overall survival Chemoradiotherapy vs chemoradiotherapy plus surgery | HR 0.99 [0.79, 1.24] | 2 studies · 431 participants | High |
Freedom from locoregional relapse Chemoradiotherapy vs chemoradiotherapy plus surgery | HR 0.55 [0.39, 0.76] | 2 studies · 431 participants | Moderate Downgraded: risk of bias |
Quality of Life Chemoradiotherapy vs chemoradiotherapy plus surgery | no estimate extracted | 1 study · 165 participants | Very low Downgraded: risk of bias, imprecision |
Treatment‐related mortality Chemoradiotherapy vs chemoradiotherapy plus surgery | RR 5.11 [1.74, 15.02] | 2 studies · 431 participants | Low Downgraded: risk of bias, imprecision |
Use of salvage procedures for dysphagia Chemoradiotherapy vs chemoradiotherapy plus surgery | RR 0.52 [0.36, 0.75] | 1 study · 259 participants | Low Downgraded: risk of bias, imprecision |