Cochrane · systematic review · CD010790
Laser therapy for retinopathy in sickle cell disease
Myint, KT, Sahoo, S, Thein, AW, et al. · Cochrane Database of Systematic Reviews · 2022 · Cochrane Library
Cystic Fibrosis and Genetic DisordersAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
6
current version
GRADE rated
5
No studies
1
Included studies
NR
No studies 1 · 16.7%Ungraded 0 · 0%Very low 3 · 50%Low 2 · 33.3%Moderate 0 · 0%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Summary of findings ‐ laser therapy compared with no laser therapy for retinopathy in sickle cell disease (SCD)
Population: children and adults with SCD and PSR
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Regression of PSR: change in number and size (in clock hours or in degrees of retinal circumference) of new blood vessels Summary of findings ‐ laser therapy vs no laser therapy | no estimate extracted | 2 studies · 247 participants | Very low Downgraded: risk of bias, imprecision, indirectness |
Development of new PSR: proliferation of blood vessels at a new area/progression of existing PSR after treatment Summary of findings ‐ laser therapy vs no laser therapy | no estimate extracted | 2 studies · 247 participants | Very low Downgraded: risk of bias, imprecision, indirectness |
Quality of life Summary of findings ‐ laser therapy vs no laser therapy | no estimate extracted | NR | No studies |
Change in visual loss associated with PSR: visual loss is defined by the deterioration of visual acuity of 3 lines or more with the Snellen chart Summary of findings ‐ laser therapy vs no laser therapy | no estimate extracted | 3 studies · 414 participants | Very low Downgraded: risk of bias, imprecision, indirectness |
Occurence of vitreous haemorrhage Summary of findings ‐ laser therapy vs no laser therapy | no estimate extracted | 3 studies · 414 participants | Low Downgraded: risk of bias, imprecision, indirectness |
Adverse effects Summary of findings ‐ laser therapy vs no laser therapy | no estimate extracted | 3 studies · 414 participants | Low Downgraded: risk of bias, imprecision, indirectness |