Cochrane · systematic review · CD012058
Gene therapy for peripheral arterial disease
Forster, R, Liew, A, Bhattacharya, V, et al. · Cochrane Database of Systematic Reviews · 2018 · Cochrane Library
VascularAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
7
current version
GRADE rated
7
No studies
0
Included studies
NR
No studies 0 · 0%Ungraded 0 · 0%Very low 2 · 28.6%Low 2 · 28.6%Moderate 3 · 42.9%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Gene therapy compared to no gene therapy control for peripheral arterial disease
Population: peripheral arterial disease
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Amputation‐free survival Gene therapy vs no gene therapy control | OR 1.68 [0.75, 3.76] | 4 studies · 756 participants | Moderate Downgraded: inconsistency |
Ulcer healing Gene therapy vs no gene therapy control | OR 2.16 [1.02, 4.59] | 5 studies · 238 participants | Low Downgraded: risk of bias, imprecision |
Quality of life Gene therapy vs no gene therapy control | no estimate extracted | 6 studies · 699 participants | Very low Downgraded: inconsistency |
Amputation (above‐ankle amputation of the index limb) Gene therapy vs no gene therapy control | OR 1.06 [0.77, 1.46] | 11 studies · 1336 participants | Moderate Downgraded: inconsistency |
All‐cause mortality Gene therapy vs no gene therapy control | OR 0.93 [0.66, 1.31] | 12 studies · 1685 participants | Moderate Downgraded: inconsistency |
ABI ‐ change from baseline Gene therapy vs no gene therapy control | no estimate extracted | 1 study · 125 participants | Low Downgraded: imprecision |
Pain symptom scores (VAS) ‐ change from baseline Gene therapy vs no gene therapy control | no estimate extracted | 2 studies · 152 participants | Very low Downgraded: risk of bias, imprecision, inconsistency |