Cochrane · systematic review · CD012326
Survival differences with immediate versus delayed chemotherapy for asymptomatic incurable metastatic colorectal cancer
Claassen, YHM, van der Valk, MJM, Breugom, AJ, et al. · Cochrane Database of Systematic Reviews · 2018 · Cochrane Library
ColorectalAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
7
current version
GRADE rated
7
No studies
0
Included studies
NR
No studies 0 · 0%Ungraded 0 · 0%Very low 4 · 57.1%Low 3 · 42.9%Moderate 0 · 0%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Delayed chemotherapy compared with immediate chemotherapy for patients with asymptomatic, incurable, metastatic colorectal cancer
Population: patients with asymptomatic, incurable, metastatic colorectal cancer
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Overall survival Delayed chemotherapy vs immediate chemotherapy | HR 1.17 [0.93, 1.46] | 3 studies · 351 participants | Low Downgraded: imprecision |
Toxicity – nausea and vomiting Delayed chemotherapy vs immediate chemotherapy | RR 0.84 [0.31, 2.25] | 2 studies · 140 participants | Very low Downgraded: imprecision |
Toxicity – stomatitis Delayed chemotherapy vs immediate chemotherapy | RR 1.1 [0.47, 2.55] | 2 studies · 140 participants | Very low Downgraded: imprecision |
Toxicity – diarrhoea Delayed chemotherapy vs immediate chemotherapy | RR 0.69 [0.34, 1.4] | 2 studies · 140 participants | Very low Downgraded: imprecision |
Quality of life Delayed chemotherapy vs immediate chemotherapy | no estimate extracted | 2 studies · 161 participants | Very low Downgraded: imprecision |
Progression‐free survival Delayed chemotherapy vs immediate chemotherapy | no estimate extracted | 3 studies · 351 participants | Low Downgraded: imprecision |
Compliance to chemotherapy Delayed chemotherapy vs immediate chemotherapy | no estimate extracted | 3 studies · 174 participants | Low Downgraded: imprecision |