Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

124 questions · 128 findings · 81 reviews · Headline outcomes only

No studies found 26 · 20.3%GRADE not reported 13 · 10.2%Very low 46 · 35.9%Low 23 · 18%Moderate 16 · 12.5%High 4 · 3.1%

Higher vs lower FiO2 or targets of arterial oxygenation

Proportion of participants with 1 or more serious adverse events according to International Conference on Harmonisation Good Clinical Practice (ICH‐GCP) · adults admitted to the ICU

It is very uncertain whether higher changes proportion of participants with ≥ 1 serious adverse events according… compared with lower FiO2 or targets of arterial oxygenation (very low certainty).

1 finding from 1 review

High‐dose vs low‐dose colchicine

Total adverse events · acute gout

High‐dose may leads to higher total adverse events compared with low‐dose colchicine (low certainty).

1 finding from 1 review