Cochrane · systematic review · CD011010
High flow nasal cannula for respiratory support in term infants
Dopper, A, Steele, M, Bogossian, F, et al. · Cochrane Database of Systematic Reviews · 2023 · Cochrane Library
NeonatalAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
14
current version
GRADE rated
9
No studies
1
Included studies
NR
No studies 1 · 7.1%Ungraded 4 · 28.6%Very low 7 · 50%Low 1 · 7.1%Moderate 1 · 7.1%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Summary of findings table ‐ High flow nasal cannula (HFNC) compared to continuous positive airway pressure (CPAP) for respiratory support in term infants (infants ≥ 37 weeks gestational age to the end of the neonatal period (up to 1 month postnatal age))
Population: respiratory support in term infants (infants ≥ 37 weeks gestational age to the end of the neonatal period (up to 1 month postnatal age))
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Death Summary of findings table ‐ High flow nasal cannula (HFNC) vs continuous positive airway pressure (CPAP) | no estimate extracted | 2 studies · 439 participants | Ungraded |
Treatment failure Summary of findings table ‐ High flow nasal cannula (HFNC) vs continuous positive airway pressure (CPAP) | RR 0.98 [0.47, 2.04] | 3 studies · 452 participants | Very low Downgraded: imprecision, inconsistency |
Chronic lung disease Summary of findings table ‐ High flow nasal cannula (HFNC) vs continuous positive airway pressure (CPAP) | no estimate extracted | 1 study · 375 participants | Ungraded |
Duration of any form of respiratory support (any form of non‐invasive respiratory support with or without supplemental oxygen) Summary of findings table ‐ High flow nasal cannula (HFNC) vs continuous positive airway pressure (CPAP) | no estimate extracted | 4 studies · 530 participants | Very low Downgraded: risk of bias, imprecision, inconsistency |
Length of stay at intensive care unit Summary of findings table ‐ High flow nasal cannula (HFNC) vs continuous positive airway pressure (CPAP) | no estimate extracted | 3 studies · 452 participants | Moderate Downgraded: imprecision |
Adverse events ‐ nasal trauma Summary of findings table ‐ High flow nasal cannula (HFNC) vs continuous positive airway pressure (CPAP) | RR 0.16 [0.04, 0.66] | 1 study · 78 participants | Very low Downgraded: risk of bias, imprecision |
Adverse events ‐ abdominal overdistention Summary of findings table ‐ High flow nasal cannula (HFNC) vs continuous positive airway pressure (CPAP) | RR 0.22 [0.07, 0.71] | 1 study · 78 participants | Very low Downgraded: risk of bias, imprecision |
Summary of findings table ‐ High flow nasal cannula (HFNC) compared to low flow nasal cannula (LFNC) for respiratory support in term infants (infants ≥ 37 weeks gestational age to the end of the neonatal period (up to 1 month postnatal age))
Population: respiratory support in term infants (infants ≥ 37 weeks gestational age to the end of the neonatal period (up to 1 month postnatal age))
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Death Summary of findings table ‐ High flow nasal cannula (HFNC) vs low flow nasal cannula (LFNC) | no estimate extracted | 2 studies · 95 participants | Ungraded |
Treatment failure Summary of findings table ‐ High flow nasal cannula (HFNC) vs low flow nasal cannula (LFNC) | RR 0.44 [0.21, 0.92] | 2 studies · 95 participants | Low Downgraded: imprecision, indirectness |
Chronic lung disease (need for supplemental oxygen at 28 days of life) ‐ not measured Summary of findings table ‐ High flow nasal cannula (HFNC) vs low flow nasal cannula (LFNC) | no estimate extracted | NR | No studies |
Duration of any form of respiratory support (any form of non‐invasive respiratory support with or without supplemental oxygen) Summary of findings table ‐ High flow nasal cannula (HFNC) vs low flow nasal cannula (LFNC) | no estimate extracted | 1 study · 74 participants | Very low Downgraded: imprecision, indirectness |
Length of stay at intensive care unit (ICU) Summary of findings table ‐ High flow nasal cannula (HFNC) vs low flow nasal cannula (LFNC) | no estimate extracted | 1 study · 74 participants | Very low Downgraded: imprecision, indirectness |
Hospital length of stay Summary of findings table ‐ High flow nasal cannula (HFNC) vs low flow nasal cannula (LFNC) | no estimate extracted | 2 studies · 95 participants | Very low Downgraded: imprecision, inconsistency, indirectness |
Adverse events Summary of findings table ‐ High flow nasal cannula (HFNC) vs low flow nasal cannula (LFNC) | no estimate extracted | 2 studies · 95 participants | Ungraded |