Cochrane · systematic review · CD012229
Ghrelin for the management of cachexia associated with cancer
Khatib, MN, Shankar, AH, Kirubakaran, R, et al. · Cochrane Database of Systematic Reviews · 2018 · Cochrane Library
Pain, Palliative and Supportive CareAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
12
current version
GRADE rated
12
No studies
0
Included studies
NR
No studies 0 · 0%Ungraded 0 · 0%Very low 12 · 100%Low 0 · 0%Moderate 0 · 0%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Ghrelin compared to placebo for cachexia associated with cancer
Population: people with cachexia associated with cancer
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Food intake Ghrelin vs placebo | no estimate extracted | 1 study · 7 participants | Very low Downgraded: risk of bias, imprecision |
Body weight Ghrelin vs placebo | no estimate extracted | NR | Very low |
Adverse events Ghrelin vs placebo | no estimate extracted | 1 study · 7 participants | Very low Downgraded: risk of bias, imprecision |
Ghrelin compared to alternative experimental treatment modality for cachexia associated with cancer
Population: people with cancer cachexia
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Food intake Ghrelin vs alternative experimental treatment modality | no estimate extracted | NR | Very low |
Body weight Ghrelin vs alternative experimental treatment modality | no estimate extracted | NR | Very low |
Adverse events Ghrelin vs alternative experimental treatment modality | no estimate extracted | NR | Very low |
Ghrelin in combination with other treatments compared to ghrelin treatment alone for cachexia associated with cancer
Population: people with cancer cachexia
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Food intake Ghrelin in combination with other treatments vs ghrelin treatment alone | no estimate extracted | NR | Very low |
Body weight Ghrelin in combination with other treatments vs ghrelin treatment alone | no estimate extracted | NR | Very low |
Adverse events Ghrelin in combination with other treatments vs ghrelin treatment alone | no estimate extracted | NR | Very low |
Higher‐dose ghrelin compared to lower‐dose ghrelin for cachexia associated with cancer
Population: people with cancer cachexia
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Food intake Higher‐dose ghrelin vs lower‐dose ghrelin | no estimate extracted | 2 studies · 40 participants | Very low Downgraded: risk of bias, imprecision |
Body weight Higher‐dose ghrelin vs lower‐dose ghrelin | no estimate extracted | NR | Very low |
Adverse events Higher‐dose ghrelin vs lower‐dose ghrelin | no estimate extracted | 2 studies · 40 participants | Very low Downgraded: risk of bias, imprecision |