Cochrane · systematic review · CD008550
Pharmacological treatment of gastro‐oesophageal reflux in children
Tighe, MP, Andrews, E, Liddicoat, I, et al. · Cochrane Database of Systematic Reviews · 2023 · Cochrane Library
GutAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
20
current version
GRADE rated
9
No studies
11
Included studies
NR
No studies 11 · 55%Ungraded 0 · 0%Very low 9 · 45%Low 0 · 0%Moderate 0 · 0%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Omeprazole compared to placebo for GORD in infants
Population: infants with GORD
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Improvement in symptoms in infants Omeprazole vs placebo | no estimate extracted | 1 study · 30 participants | Very low Downgraded: risk of bias, imprecision |
Adverse events ‐ not reported Omeprazole vs placebo | no estimate extracted | NR | No studies |
Improvement in pH metrics in infants Omeprazole vs placebo | no estimate extracted | 1 study · 30 participants | Very low Downgraded: risk of bias, imprecision |
Endoscopic metrics ‐ not measured Omeprazole vs placebo | no estimate extracted | NR | No studies |
Omeprazole compared to ranitidine for GORD in infants
Population: GORD in infants
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Improvement in symptoms in infants Omeprazole vs ranitidine | no estimate extracted | 1 study · 60 participants | Very low Downgraded: risk of bias, imprecision |
Adverse events in infants ‐ not measured Omeprazole vs ranitidine | no estimate extracted | NR | No studies |
Improvement in pH metrics in infants ‐ not measured Omeprazole vs ranitidine | no estimate extracted | NR | No studies |
Improvement in endoscopic findings in infants ‐ not measured Omeprazole vs ranitidine | no estimate extracted | NR | No studies |
Esomeprazole compared to placebo for GORD in infants
Population: GORD in infants
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Improvement in symptoms and signs in infants Esomeprazole vs placebo | no estimate extracted | 1 study · 52 participants | Very low Downgraded: risk of bias, imprecision, indirectness, publication bias |
Adverse events ‐ not reported Esomeprazole vs placebo | no estimate extracted | NR | No studies |
pH indices ‐ not measured Esomeprazole vs placebo | no estimate extracted | NR | No studies |
Endoscopic metrics ‐ not measured Esomeprazole vs placebo | no estimate extracted | NR | No studies |
Rabeprazole at higher doses (1 mg/kg) compared to rabeprazole at lower doses (0.5 mg/kg) for GORD in children over 1 year of age
Population: GORD in children over 1 year of age
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Improvement in symptoms Rabeprazole at higher doses (1 mg/kg) vs rabeprazole at lower doses (0.5 mg/kg) | no estimate extracted | 1 study · 127 participants | Very low Downgraded: risk of bias, imprecision, publication bias |
Adverse events Rabeprazole at higher doses (1 mg/kg) vs rabeprazole at lower doses (0.5 mg/kg) | no estimate extracted | 1 study · 127 participants | Very low Downgraded: risk of bias, imprecision, publication bias |
Improvement in endoscopic appearances Rabeprazole at higher doses (1 mg/kg) vs rabeprazole at lower doses (0.5 mg/kg) | no estimate extracted | 1 study · 127 participants | Very low Downgraded: risk of bias, imprecision, publication bias |
pH indices ‐ not measured Rabeprazole at higher doses (1 mg/kg) vs rabeprazole at lower doses (0.5 mg/kg) | no estimate extracted | NR | No studies |
Pantoprazole in higher doses (1.2 mg/kg) compared to pantoprazole at lower doses (0.3 mg/kg) for GORD in children over 1 year of age
Population: GORD in children over 1 year of age
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Improvement in symptoms Pantoprazole in higher doses (1.2 mg/kg) vs pantoprazole at lower doses (0.3 mg/kg) | no estimate extracted | 1 study · 60 participants | Very low Downgraded: risk of bias, imprecision, publication bias |
Adverse events Pantoprazole in higher doses (1.2 mg/kg) vs pantoprazole at lower doses (0.3 mg/kg) | no estimate extracted | 1 study · 60 participants | Very low Downgraded: risk of bias, imprecision, publication bias |
Improvement in pH indices ‐ not measured Pantoprazole in higher doses (1.2 mg/kg) vs pantoprazole at lower doses (0.3 mg/kg) | no estimate extracted | NR | No studies |
Improvement in endoscopic metrics ‐ not measured Pantoprazole in higher doses (1.2 mg/kg) vs pantoprazole at lower doses (0.3 mg/kg) | no estimate extracted | NR | No studies |